Lifetime surgical exposure, episodic memory, and forniceal microstructure in older adults

Journal of Clinical and Experimental Neuropsychology
James R BatemanBrianne M Bettcher

Abstract

Introduction: Aging is associated with heterogeneous cognitive trajectories. There is considerable interest in identifying risk factors for pathological aging, with recent studies demonstrating a link between surgical procedures and proximal cognitive decline; however, the role of lifetime exposure to surgical procedures and cognitive function has been relatively unexplored. This pilot study aimed to evaluate the association between total lifetime surgical procedures and memory function in older adults. Methods: A cohort of 62 older adults underwent a neuropsychological evaluation and health history assessment. Self-reported lifetime surgical history was categorized as "cardiac" or "non-cardiac." General linear models were fit with demographics as nuisance covariates, and the total number of non-cardiac surgeries as our predictor of interest. Total scores on measures of episodic memory, language, working memory, fluency, and visuospatial function were separate outcome variables. In a secondary analysis, vascular risk factors were included as covariates. Diffusion tensor imaging was obtained for exploratory analyses of selected regions of interest. Results: The mean age of participants was 70, and 0-13 lifetime non-cardiac surgi...Continue Reading

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Citations

Jun 23, 2020·Brain Connectivity·Susan L BenearIngrid R Olson

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Methods Mentioned

BETA
sedation

Software Mentioned

Brain Extraction Tool ( BET )
FSL
FSL DTIFIT
FMRIB
Diffusion Toolbox ( FDT )
fslstats
FMRIB Software Library ( FSL )
SENAS

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