Lifitegrast, a Novel Integrin Antagonist for Treatment of Dry Eye Disease

The Ocular Surface
Victor L PerezReza Haque

Abstract

The etiology of dry eye disease (DED) is complex and not yet fully understood, but the disease is now recognized as being associated with ocular surface inflammation. The latest advances in the understanding of the pathophysiology of DED have directed the focus of recent drug development to target the inflammatory pathways involved in the disease. Lifitegrast is a novel small molecule integrin antagonist that inhibits T cell-mediated inflammation by blocking the binding of two important cell surface proteins (lymphocyte function-associated antigen 1 and intercellular adhesion molecule 1), thus lessening overall inflammatory responses. This review highlights the role of T cells and integrins in the inflammatory process involved in the pathophysiology of DED and outlines the scientific rationale for the role of lifitegrast. In addition, the preclinical development, pharmacological properties, clinical efficacy, and safety of lifitegrast are described.

References

Oct 21, 1999·Clinical Immunology : the Official Journal of the Clinical Immunology Society·S M WhitcupM T Magone
Nov 6, 2003·Journal of Cell Science·Nancy HoggAlison McDowall
Dec 8, 2004·Current Drug Metabolism·Sridhar DuvvuriAshim K Mitra
May 26, 2007·Investigative Ophthalmology & Visual Science·Cintia S De PaivaStephen C Pflugfelder
Aug 30, 2008·Blood·Jinfang Zhu, William E Paul
Nov 11, 2008·American Journal of Ophthalmology·Helene LamStephen C Pflugfelder
Feb 27, 2009·Mucosal Immunology·C S De PaivaS C Pflugfelder
Apr 3, 2009·Investigative Ophthalmology & Visual Science·Jaafar El AnnanReza Dana
Jun 6, 2009·Critical Reviews in Immunology·Christopher C DenucciYoji Shimizu
Jun 18, 2009·Mucosal Immunology·S K Chauhan, R Dana
Jul 23, 2009·Proceedings of the National Academy of Sciences of the United States of America·Niña C HartmanJay T Groves
Mar 26, 2010·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Charles P SembaThomas R Gadek
May 4, 2010·The AAPS Journal·Ripal GaudanaAshim K Mitra
Jul 27, 2010·Bioorganic & Medicinal Chemistry Letters·Min ZhongW Mike Flanagan
May 7, 2011·Theranostics·Melissa MillardNouri Neamati
May 29, 2012·Trends in Pharmacological Sciences·Simon L Goodman, Martin Picard
Jul 26, 2012·ISRN Pharmaceutics·Ketan T SavjaniJignasa K Savjani
Oct 11, 2012·Journal of Ophthalmology·Frederick T FraunfelderWilliam D Mathers
Dec 12, 2012·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Yan SunEric Pearlman
Jan 31, 2013·International Reviews of Immunology·Michael E SternStephen C Pflugfelder
Sep 23, 2014·Chemistry & Biology·Michelle R ArkinJames A Wells

❮ Previous
Next ❯

Citations

Oct 30, 2016·Expert Opinion on Investigational Drugs·Marcella NebbiosoAlessandro Lambiase
Dec 3, 2016·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Stephen C PflugfelderAmir Shojaei
Mar 11, 2017·International Ophthalmology Clinics·Cintia S de Paiva
Aug 15, 2017·International Journal of Molecular Sciences·Marcella NebbiosoAlessandro Lambiase
Dec 22, 2017·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Jou-Ku ChungDevin Welty
Feb 15, 2018·Oxidative Medicine and Cellular Longevity·Lian CuiKyung Chul Yoon
Nov 9, 2017·Expert Opinion on Pharmacotherapy·Candela Rodríguez-PomarGonzalo Carracedo
Dec 14, 2017·Scientific Reports·Michelle L RataySteven R Little
Oct 17, 2017·Advanced Healthcare Materials·Michelle L RataySteven R Little
Jun 30, 2018·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Rodrigo Guimaraes de SouzaCintia S de Paiva
Nov 1, 2017·Seminars in Ophthalmology·Roberto Gonzalez-SalinasHugo Quiroz-Mercado
Jul 15, 2018·Current Eye Research·Cameron K PostnikoffKelly K Nichols
Aug 8, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Stephani Joy Y MacalinoSun Choi
Aug 11, 2018·Ocular Immunology and Inflammation·Antonio Abengózar-VelaMaría Jesús González-García
Sep 15, 2017·Ocular Immunology and Inflammation·Carlo Alberto CutoloCarlo Enrico Traverso
Jul 12, 2019·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·Sunao TanakaJunji Itou
Nov 26, 2019·Leukemia & Lymphoma·Saurabh ChhabraMehdi Hamadani
Mar 17, 2020·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Laura M PerimanPiergiorgio Neri
Aug 26, 2017·Expert Opinion on Pharmacotherapy·Eric D DonnenfeldEric D Rosenberg
Mar 11, 2017·International Ophthalmology Clinics·Stephen C PflugfelderAnastasia Alex
Nov 15, 2019·Organic & Biomolecular Chemistry·Dan ZhangWenhao Hu
Jul 25, 2020·The British Journal of Ophthalmology·Pasquale AragonaMaurizio Rolando
Sep 17, 2020·Biomedicines·Dmitry V ChistyakovEvgeni Yu Zernii
Sep 2, 2016·Current Opinion in Allergy and Clinical Immunology·Brett P BieloryLeonard Bielory
Mar 13, 2018·Frontiers in Medicine·Victor J DrewThierry Burnouf
Sep 25, 2020·Signal Transduction and Targeted Therapy·Haiying LuJianyou Shi
Aug 24, 2017·Cancers·Sabine Raab-WestphalSimon L Goodman
Dec 3, 2020·Journal of Glaucoma·Adam MuzychukMona Harissi-Dagher
May 30, 2020·The Ocular Surface·Nai-Wen FanReza Dana
Jan 25, 2021·Experimental Eye Research·Ruchi ShahAlexander V Ljubimov
Dec 31, 2020·International Journal of Molecular Sciences·M Elizabeth FiniMark R Wilson
Sep 6, 2020·The Ocular Surface·Cameron K PostnikoffKelly K Nichols
Apr 4, 2021·Survey of Ophthalmology·Mohansrinivas ChennakesavaluDimitri T Azar

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anti-inflammatory Treatments

A drug or substance that reduces inflammation (redness, swelling, and pain) in the body. Anti-inflammatory agents block certain substances in the body that cause inflammation and swelling. Discover the latest research on anti-inflammatory treatments here

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.