Ligand-assisted palladium-catalyzed C-H alkenylation of aliphatic amines for the synthesis of functionalized pyrrolidines

Chemical Science
Chuan He, Matthew J Gaunt

Abstract

The development of a ligand-assisted Pd-catalyzed C-H alkenylation of aliphatic amines is reported. Our studies indicated that an amino-acid-derived ligand renders the C-H bond activation step reversible and promotes the traditionally difficult alkenylation process. The C(sp3)-H alkenylation proceeds through a 5-membered-ring cyclopalladation pathway that allows access to complex aliphatic heterocycles that could be useful to practioners of synthetic and medicinal chemistry.

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Nov 22, 2018·Angewandte Chemie·Padon ChuentragoolVladimir Gevorgyan
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Jul 24, 2018·Chemical Society Reviews·Carlo SambiagioMichael Schnürch
Jun 8, 2021·Chemical Science·Jayabrata DasDebabrata Maiti
Jun 25, 2021·Chemical Science·Wajid AliDebabrata Maiti
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May 23, 2018·Journal of the American Chemical Society·Mohit KapoorMichael C Young
Feb 18, 2020·Chemical Reviews·Aaron TrowbridgeMatthew J Gaunt
Feb 4, 2022·Chemical Communications : Chem Comm·Srinivasarao Arulananda BabuRadha Tomar

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