Ligand binding and affinity modulation of integrins

Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire
E C TozerJ C Loftus

Abstract

Integrins are cell adhesion receptors that mediate cell-cell and cell-extracellular matrix interactions. The extracellular domains of these receptors possess binding sites for a diverse range of protein ligands. Ligand binding is divalent cation dependent and involves well-defined motifs in the ligand. Integrins can dynamically regulate their affinity for ligands (inside-out signaling). This ability to rapidly modulate their affinity state is key to their involvement in such processes as cell migration and platelet aggregation. This review will focus on two aspects of integrin function: first, on the molecular basis of ligand-integrin interactions and, second, on the underlying mechanisms controlling the affinity state of integrins for their ligands.

References

Nov 1, 1979·The Journal of Clinical Investigation·J S Bennett, G Vilaire
Jan 1, 1992·The Journal of Cell Biology·I DransfieldN Hogg
May 1, 1992·The Journal of Cell Biology·A G ArroyoF Sánchez-Madrid
Oct 1, 1992·Current Opinion in Cell Biology·M H GinsbergE F Plow
Nov 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·D H FarrellE W Davie
Sep 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·R Yaghmai, G L Hazelbauer
Aug 1, 1990·The Journal of Cell Biology·C A OteyK Burridge
Nov 5, 1988·Journal of Molecular Biology·Y S BabuW J Cook
Oct 5, 1988·Journal of Molecular Biology·O Herzberg, M N James
Jul 1, 1983·The Journal of Clinical Investigation·Z M RuggeriR R Montgomery
Mar 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·J HawigerR F Doolittle
Mar 1, 1994·The Journal of Cell Biology·T E O'TooleM H Ginsberg
Oct 25, 1994·Proceedings of the National Academy of Sciences of the United States of America·T UedaM A Arnaout
Oct 1, 1994·Current Opinion in Cell Biology·S J ShattilJ S Brugge
Sep 1, 1995·The Journal of Cell Biology·M D SchallerJ T Parsons
Sep 1, 1993·The Journal of Cell Biology·D T ShihC A Buck
Apr 14, 1995·The Journal of Biological Chemistry·T E O'TooleB M Culley

❮ Previous
Next ❯

Citations

Mar 22, 2005·Biochimica Et Biophysica Acta·Hiroaki HirataHidetake Miyata
Dec 24, 1997·Matrix Biology : Journal of the International Society for Matrix Biology·K M Yamada
Nov 21, 2012·Molecular Therapy : the Journal of the American Society of Gene Therapy·Lydia W T CheungAlice S T Wong
May 10, 2008·BMC Evolutionary Biology·Brent A KnackDavid J Miller
Aug 22, 2009·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Hakan CamuzcuogluNurten Aksoy
May 27, 2006·Cancer Letters·Michael Z Gilcrease
Mar 28, 2002·Biophysical Journal·Daniel Irimia, Jens O M Karlsson
May 18, 1999·The American Journal of Pathology·K LessanA P Skubitz
Feb 14, 1998·Nature·C Bargmann
Jul 26, 2002·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·P A Whiss, R G G Andersson
Nov 29, 2002·The Journal of Biological Chemistry·Paola SpessottoAlfonso Colombatti

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.

Cell Migration

Cell migration is involved in a variety of physiological and pathological processes such as embryonic development, cancer metastasis, blood vessel formation and remoulding, tissue regeneration, immune surveillance and inflammation. Here is the latest research.

© 2021 Meta ULC. All rights reserved