PMID: 9541543Apr 29, 1998Paper

Ligand-binding domains in vitellogenin receptors and other LDL-receptor family members share a common ancestral ordering of cysteine-rich repeats

Journal of Molecular Evolution
T W Sappington, A S Raikhel

Abstract

Insect vitellogenin and yolk protein receptors (VgR/YPR) are newly discovered members of the low-density lipoprotein receptor (LDLR) family, which is characterized by a highly conserved arrangement of repetitive modular elements homologous to functionally unrelated proteins. The insect VgR/YPRs are unique in having two clusters of complement-type cysteine-rich (class A) repeats or modules, with five modules in the first cluster and seven in the second cluster, unlike classical LDLRs which have a single seven-module cluster, vertebrate VgRs and very low density lipoprotein receptors (VLDLR) which have a single eight-module cluster, and LDLR-related proteins (LRPs) and megalins which have four clusters of 2-7, 8, 10, and 11 modules. Alignment of clusters across subfamilies by conventional alignment programs is problematic because of the repetitive nature of the component modules which may have undergone rearrangements, duplications, and deletions during evolution. To circumvent this problem, we "fingerprinted" each class A module in the different clusters by identifying those amino acids that are both relatively conserved and relatively unique within the cluster. Intercluster reciprocal comparisons of fingerprints and aligned seq...Continue Reading

References

Oct 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·S TakahashiT Yamamoto
Jan 1, 1985·Annual Review of Cell Biology·J L GoldsteinW J Schneider
Mar 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·M BownesA Coulson
Apr 4, 1986·Science·M S Brown, J L Goldstein
Oct 6, 1995·The Journal of Biological Chemistry·H BujoW J Schneider
Jul 1, 1995·Journal of the American Society of Nephrology : JASN·M G FarquharR A Orlando
Jul 3, 1995·Proceedings of the National Academy of Sciences of the United States of America·N L DalyR Smith
Jul 1, 1995·Insect Biochemistry and Molecular Biology·T W SappingtonA S Raikhel
Aug 1, 1995·Proceedings of the National Academy of Sciences of the United States of America·S EbinaT Gotoh
Feb 28, 1995·Proceedings of the National Academy of Sciences of the United States of America·C P SchonbaumA P Mahowald
Oct 11, 1994·Proceedings of the National Academy of Sciences of the United States of America·A SaitoM G Farquhar
Sep 10, 1994·Annals of the New York Academy of Sciences·J Nimpf, W J Schneider
May 24, 1994·Proceedings of the National Academy of Sciences of the United States of America·C P TensenE Vreugdenhil
May 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·J Yochem, I Greenwald
Jul 16, 1996·Biochemical and Biophysical Research Communications·K OkabayashiH Sugino
Aug 20, 1996·Proceedings of the National Academy of Sciences of the United States of America·T W SappingtonA S Raikhel

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Citations

Dec 21, 2000·Current Atherosclerosis Reports·W J SchneiderM Drexler
Dec 4, 2008·Progress in Lipid Research·Patrick J Babin, Geoffrey F Gibbons
Jul 24, 2014·Archives of Insect Biochemistry and Physiology·Mayura VeeranaLertluk Ngernsiri
Mar 1, 2005·Differentiation; Research in Biological Diversity·Jia L Song, Gary M Wessel
Jan 3, 2016·Bone·Neha S Dole, Anne M Delany
Jul 25, 2013·Journal of Lipid Research·Olav M AndersenBirthe B Kragelund
Aug 1, 2010·Biomolecular Concepts·Dick J Van der Horst, Kees W Rodenburg
Jan 14, 2012·International Journal of Psychology : Journal International De Psychologie·Mohsen Joshanloo
Apr 21, 2012·Western Journal of Nursing Research·Marlene Z Cohen Rabbi Mendel Katzman
Jan 9, 2009·Molecular and Cellular Biochemistry·Dick J Van der HorstKees W Rodenburg
Oct 29, 1998·Biochemical and Biophysical Research Communications·Y DongD Chen

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