Ligand-controlled interaction of histone acetyltransferase binding to ORC-1 (HBO1) with the N-terminal transactivating domain of progesterone receptor induces steroid receptor coactivator 1-dependent coactivation of transcription

Molecular Endocrinology
Maria GeorgiakakiHugues Loosfelt

Abstract

Modulators of cofactor recruitment by nuclear receptors are expected to play an important role in the coordination of hormone-induced transactivation processes. To identify such factors interacting with the N-terminal domain (NTD) of the progesterone receptor (PR), we used this domain as bait in the yeast Sos-Ras two-hybrid system. cDNAs encoding the C-terminal MYST (MOZ-Ybf2/Sas3-Sas2-Tip60 acetyltransferases) domain of HBO1 [histone acetyltransferase binding to the origin recognition complex (ORC) 1 subunit], a member of the MYST acetylase family, were thus selected from a human testis cDNA library. In transiently transfected CV1 cells, the wild-type HBO1 [611 amino acids (aa)] enhanced transcription mediated by steroid receptors, notably PR, mineralocorticoid receptor, and glucocorticoid receptor, and strongly induced PR and estrogen receptor coactivation by steroid receptor coactivator 1a (SRC-1a). As assessed by two-hybrid and glutathione-S-transferase pull-down assays, the HBO1 MYST acetylase domain (aa 340-611) interacts mainly with the NTD, and also contacts the DNA-binding domain and the hinge domains of hormone-bound PR. The HBO1 N-terminal region (aa 1-340) associates additionally with PR ligand-binding domain (LBD)....Continue Reading

References

Dec 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·H LoosfeltE Milgrom
Jan 1, 1995·Molecular Biology Reports·C Transy, P Legrain
Dec 19, 1995·Proceedings of the National Academy of Sciences of the United States of America·W L KrausB S Katzenellenbogen
May 14, 1996·Proceedings of the National Academy of Sciences of the United States of America·H HongM R Stallcup
Sep 17, 1996·Proceedings of the National Academy of Sciences of the United States of America·E M McInerneyB S Katzenellenbogen
Oct 1, 1996·Proceedings of the National Academy of Sciences of the United States of America·T P YaoD M Livingston
Jun 1, 1997·Molecular and Cellular Biology·A AronheimM Karin
Aug 5, 1997·Proceedings of the National Academy of Sciences of the United States of America·H LiJ D Chen
Sep 20, 1997·Nature·T E SpencerB W O'Malley
Jan 13, 1998·Biochemical and Biophysical Research Communications·K NishidaS Kitazawa
Jun 17, 1998·Genes & Development·J C BlancoK Ozato
Oct 17, 1998·Molecular Endocrinology·P WebbP J Kushner
Jun 11, 1999·The Journal of Biological Chemistry·M E BradyC N Robson
Aug 7, 1999·The Journal of Biological Chemistry·M Iizuka, B Stillman
Mar 18, 2000·The Journal of Biological Chemistry·A ChauchereauH Loosfelt
May 24, 2000·The Journal of Steroid Biochemistry and Molecular Biology·F ArcuriM Cintorino
Jun 6, 2000·Microbiology and Molecular Biology Reviews : MMBR·D E Sterner, S L Berger
Aug 10, 2000·The Journal of Biological Chemistry·M SharmaZ Sun
Mar 30, 2001·The Journal of Biological Chemistry·T W BurkeJ R Nevins
Oct 10, 2001·The Journal of Biological Chemistry·L GaughanC N Robson
Nov 22, 2001·The Journal of Biological Chemistry·Jennifer K RicherKathryn B Horwitz

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Citations

Aug 8, 2008·The Journal of Biological Chemistry·Rebecca L FoyMaria V Panchenko
Oct 4, 2008·Genes & Development·Benoit Miotto, Kevin Struhl
Dec 15, 2010·Molecular and Cellular Biology·Andrew J KuehTim Thomas
Oct 24, 2007·Molecular and Cellular Biology·Masayoshi IizukaM Mitchell Smith
Nov 3, 2010·Journal of Experimental & Clinical Cancer Research : CR·Wen-zhong WangJian-xin Gu
Jan 29, 2011·Molecular Endocrinology·Larbi AmazitAnne Guiochon-Mantel
Aug 6, 2011·Molecular Endocrinology·Junaid A KhanHugues Loosfelt
Mar 15, 2012·Molecular and Cellular Endocrinology·Nathalie Chabbert-BuffetPhilippe Bouchard
Jul 8, 2015·Cell Cycle·Nirodhini S SiriwardanaMaria V Panchenko
Dec 24, 2011·Acta Biochimica Et Biophysica Sinica·Wei-Jian SunZhi-Qiang Zheng
Apr 18, 2014·Cell Cycle·Nirodhini S SiriwardanaMaria V Panchenko
May 15, 2013·The Journal of Steroid Biochemistry and Molecular Biology·Susana CunhaMaria Cristina Oliveira
Nov 20, 2012·The American Journal of Pathology·Andrea HavasiMaria V Panchenko
Dec 6, 2016·Scientific Reports·Jing Jing LiFrancesca-Fang Liao
Apr 13, 2013·Molecular Endocrinology·Junaid A KhanMarie-Edith Rafestin-Oblin
Aug 31, 2006·The Journal of Clinical Endocrinology and Metabolism·Jiangang ChenBill L Lasley
Mar 18, 2009·Molecular Pharmacology·Isabelle Petit-TopinMarie-Edith Rafestin-Oblin
Jun 2, 2016·International Journal of Molecular Medicine·Ling-Li GuoMeng Li
Aug 26, 2018·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Anne K Voss, Tim Thomas
Apr 18, 2009·Molecular Cancer Research : MCR·Xiaolan HuGuy Cavet
Aug 21, 2013·Cancer Research·Mylinh T DuongKhandan Keyomarsi

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