Ligand customization and DNA functionalization of gold nanorods via round-trip phase transfer ligand exchange

Langmuir : the ACS Journal of Surfaces and Colloids
Andy Wijaya, Kimberly Hamad-Schifferli

Abstract

Customizable ligand exchange of gold nanorods (NRs) is described. NRs are synthesized with the cationic surfactant cetyltrimethylammonium bromide (CTAB) which is exchanged with thiolated ligands that enable suspension in buffer. Exchange is achieved by a two phase extraction. First, CTAB is removed from the NR-CTAB by extracting the NRs into an organic phase via the ligand dodecanethiol (DDT). The NR-DDT are then extracted into an aqueous phase by mercaptocarboxylic acids (MCA), HS-(CH 2)n -COOH (n = 5, 10, and 15). Ligands can be further customized to thiolated poly(ethylene glycol), PEG MW (MW = 356, 5000, and 1000). Ligand-exchanged NRs (NR-MCA and NR-PEG(MW)) are stable in buffer, do not aggregate, and do not change size upon ligand exchange. They can be run in agarose gel electrophoresis with narrow bands, indicating uniform charge distribution and enabling quantitative analysis. DNA functionalization of NR-MCA is straightforward and quantifiable, with minimal nonspecific adsorption.

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Jun 27, 2013·Analytical Chemistry·Jang Ho Joo, Jae-Seung Lee
Jul 9, 2011·Journal of the American Chemical Society·Ryan HuschkaNaomi J Halas
Apr 16, 2011·Langmuir : the ACS Journal of Surfaces and Colloids·Cyrill KueminHeiko Wolf
Mar 17, 2011·ACS Nano·Christin GrabinskiSaber M Hussain
Jul 19, 2012·ACS Nano·James Chen Yong KahKimberly Hamad-Schifferli
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Aug 6, 2013·ACS Sustainable Chemistry & Engineering·Sergio Dominguez-MedinaStephan Link
Mar 1, 2012·Langmuir : the ACS Journal of Surfaces and Colloids·James Chen Yong KahKimberly Hamad-Schifferli
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