Ligand-free Pd-catalyzed and copper-assisted C-H arylation of quinazolin-4-ones with aryl iodides under microwave heating

Organic Letters
Sylvain LaclefThierry Besson

Abstract

A microwave-assisted method for the palladium-catalyzed direct arylation of quinazolin-4-one has been developed under copper-assistance. This method is applicable to a wide range of aryl iodides and substituted (2H)-quinazolin-4-ones. This protocol provides a simple and efficient way to synthesize biologically relevant 2-arylquinazolin-4-one backbones.

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Citations

May 20, 2017·The Journal of Organic Chemistry·Dnyaneshwar N GaradSantosh B Mhaske
Jul 20, 2017·The Journal of Organic Chemistry·Wong PhakhodeeMookda Pattarawarapan
Aug 15, 2017·Organic & Biomolecular Chemistry·Aniket V A GholapAnant R Kapdi
Mar 13, 2019·Chemistry, an Asian Journal·Jala Ranjith, Palakodety Radha Krishna
Nov 26, 2019·Chemistry : a European Journal·Yue WuWanbin Zhang
May 30, 2020·Organic & Biomolecular Chemistry·Prasanjit GhoshSajal Das
Oct 8, 2020·Organic & Biomolecular Chemistry·Alexey A AkulovBert U W Maes

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