PMID: 9450949Mar 7, 1998Paper

Ligand-insensitive state of cardiac ATP-sensitive K+ channels. Basis for channel opening

The Journal of General Physiology
A E AlekseevA Terzic

Abstract

The mechanism by which ATP-sensitive K+ (KATP) channels open in the presence of inhibitory concentrations of ATP remains unknown. Herein, using a four-state kinetic model, we found that the nucleotide diphosphate UDP directed cardiac KATP channels to operate within intraburst transitions. These transitions are not targeted by ATP, nor the structurally unrelated sulfonylurea glyburide, which inhibit channel opening by acting on interburst transitions. Therefore, the channel remained insensitive to ATP and glyburide in the presence of UDP. "Rundown" of channel activity decreased the efficacy with which UDP could direct and maintain the channel to operate within intraburst transitions. Under this condition, the channel was sensitive to inhibition by ATP and glyburide despite the presence of UDP. This behavior of the KATP channel could be accounted for by an allosteric model of ligand-channel interaction. Thus, the response of cardiac KATP channels towards inhibitory ligands is determined by the relative lifetime the channel spends in a ligand-sensitive versus -insensitive state. Interconversion between these two conformational states represents a novel basis for KATP channel opening in the presence of inhibitory concentrations of ...Continue Reading

References

Nov 1, 1992·Pflügers Archiv : European journal of physiology·B Allard, M Lazdunski
Jan 1, 1990·Cellular Signalling·S J Ashcroft, F M Ashcroft
Aug 1, 1986·Pflügers Archiv : European journal of physiology·I Findlay, M J Dunne
Sep 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·S MislerM L McDaniel
Feb 1, 1987·Pflügers Archiv : European journal of physiology·T Ohno-ShosakuG Trube
Jan 1, 1988·The Journal of Membrane Biology·I Findlay
May 1, 1988·Pflügers Archiv : European journal of physiology·Y ZilberterB Khodorov
Jan 1, 1989·Pflügers Archiv : European journal of physiology·D Thuringer, D Escande
Feb 1, 1985·The Journal of Clinical Investigation·J Weiss, B Hiltbrand
Dec 1, 1994·The Journal of Membrane Biology·H Parnas, I Parnas
Jan 1, 1994·Journal of Cardiovascular Pharmacology·G Bönner
Jan 1, 1994·Journal of Cardiovascular Pharmacology·M Lazdunski
Jan 1, 1994·Journal of Cardiovascular Pharmacology·I Findlay
Jun 1, 1994·Cardiovascular Research·A TerzicY Kurachi
Dec 1, 1993·The Journal of Membrane Biology·T FurukawaM Hiraoka
Dec 1, 1993·The Journal of Membrane Biology·D G WardJ D Cavieres
Aug 1, 1993·Cardiovascular Drugs and Therapy·J N Weiss, N Venkatesh
Jul 1, 1993·Progress in Neurobiology·M Takano, A Noma
Feb 17, 1993·Molecular and Cellular Biochemistry·L VirágM Hiraoka
Feb 1, 1993·The Journal of Membrane Biology·B TraxlerJ Beckwith

❮ Previous
Next ❯

Citations

Jun 28, 2005·Journal of Molecular and Cellular Cardiology·Andrey P Babenko
May 25, 2005·Journal of Molecular and Cellular Cardiology·Shozeb HaiderFrances M Ashcroft
Feb 13, 2001·Biophysical Journal·D EnkvetchakulC G Nichols
Mar 26, 2004·Biophysical Journal·Peter DrainLehong Li
Apr 30, 1998·Journal of the American College of Cardiology·P A Brady, A Terzic
Oct 6, 2009·Acta Pharmacologica Sinica·Xi-Sheng YanPei-Hua Zhang
Sep 21, 2000·European Journal of Biochemistry·T Baukrowitz, B Fakler
Sep 5, 2009·The Journal of Biological Chemistry·Mingming Hao, Jonathan S Bogan
Oct 29, 2003·The Journal of General Physiology·D Enkvetchakul, C G Nichols
Sep 1, 2005·The Journal of General Physiology·Lehong LiPeter Drain
Feb 27, 2008·The Journal of General Physiology·Amy B KargerAlexey E Alekseev
Jul 2, 2008·The Journal of General Physiology·Tim J CraigPeter Proks
Sep 30, 2010·The Journal of General Physiology·Peter ProksFrances M Ashcroft
Jun 8, 2001·Proceedings of the National Academy of Sciences of the United States of America·A J CarrascoA Terzic
Oct 16, 1999·Proceedings of the National Academy of Sciences of the United States of America·N D'hahanM Vivaudou
Aug 24, 1999·The Journal of Physiology·E L HolmuhamedovA Terzic
Nov 6, 2008·Progress in Biophysics and Molecular Biology·Peter Proks, Frances M Ashcroft
Apr 9, 2017·The Journal of General Physiology·William F BorschelColin G Nichols
May 2, 2000·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·A D Harrower
Jul 21, 2007·Journal of Applied Physiology·L V ZingmanA Terzic
Jan 21, 2010·Physiological Reviews·Hiroshi HibinoYoshihisa Kurachi
Oct 22, 2002·American Journal of Physiology. Cell Physiology·Zheng FanWenxia Wang
Dec 15, 2015·Physiological Reviews·Monique N Foster, William A Coetzee
Oct 12, 2000·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·M BienengraeberA Terzic
May 12, 1998·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·P P Dzeja, A Terzic
Nov 2, 1999·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·M R AbrahamA Terzic
Nov 14, 1998·The American Journal of Physiology·E L HolmuhamedovA Terzic

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.