Ligand-lipid and ligand-core affinity control the interaction of gold nanoparticles with artificial lipid bilayers and cell membranes

Nanomedicine : Nanotechnology, Biology, and Medicine
Janine BrodaWolfgang Wenzel

Abstract

Interactions between nanoparticles (NPs) and biomembranes depend on the physicochemical properties of the NPs, such as size and surface charge. Here we report on the size-dependent interaction of gold nanoparticles (AuNPs), stabilized with ligands differing in charge, i.e. sodium 3-(diphenylphosphino)benzene sulfonate (TPPMS) and sodium 3,3',3″-triphenylphosphine sulfonate (TPPTS), respectively, with artificial membranes (black lipid membranes; BLMs) and HeLa cells. The TPPTS-stabilized AuNPs affect BLMs at lower size than TPPMS-stabilized ones. On HeLa cells we found decreasing cytotoxicity with increasing particle size, however, with an overall lower cytotoxicity for TPPTS-stabilized AuNPs. We attribute size-dependent BLM properties as well as reduced cytotoxicity of TPPTS-stabilized AuNPs to weaker shielding of the AuNP core when stabilized with TPPTS. We hypothesize that the partially unshielded hydrophobic gold core can embed into the hydrophobic membrane interior. Thereby we demonstrate that ligand-dependent cytotoxicity of NP can occur even when the NPs are not translocated through the membrane. The use of nanoparticles (NPs) in the clinical setting means that there will be interactions between NPs and cell membranes. Th...Continue Reading

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Citations

Jul 14, 2017·Archives of Toxicology·Günter SchmidUlrich Simon
Dec 29, 2020·Nanoscale·Cecilia SpedalieriJanina Kneipp
Feb 13, 2021·Nanoscale Horizons : the Home for Rapid Reports of Exceptional Significance in Nanoscience and Nanotechnolgy·Luís EstroncaLino Ferreira
Jan 9, 2018·Langmuir : the ACS Journal of Surfaces and Colloids·Nasim GanjiGeoffrey D Bothun
Jul 10, 2019·The Journal of Physical Chemistry. B·Xingyao FengAyumi Hirano-Iwata

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