Ligand-Promoted Rhodium(III)-Catalyzed ortho-C-H Amination with Free Amines

Angewandte Chemie
Huai-Wei WangJin-Quan Yu

Abstract

Ligand development for rhodium(III)-catalyzed C-H activation reactions has largely been limited to cyclopentadienyl (Cp) based scaffolds. 2-Methylquinoline has now been identified as a feasible ligand that can coordinate to the metal center of Cp*RhCl to accelerate the cleavage of the C-H bond of N-pentafluorophenylbenzamides, providing a new structural lead for ligand design. The compatibility of this reaction with secondary free amines and anilines also overcomes the limitations of palladium(II)-catalyzed C-H amination reactions.

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Citations

Jul 24, 2018·Chemical Society Reviews·Carlo SambiagioMichael Schnürch
Nov 10, 2018·Chemical Communications : Chem Comm·Tingting YuanYangjie Wu
Nov 21, 2018·Angewandte Chemie·Martin Pichette DrapeauLukas J Gooßen
Apr 26, 2019·Chemical Communications : Chem Comm·Rui-Hua LiuTeck-Peng Loh
Sep 19, 2019·Chemical Communications : Chem Comm·Ze-Yu Tian, Cheng-Pan Zhang
Apr 24, 2019·Nature Chemistry·Alessandro RuffoniDaniele Leonori
Dec 1, 2019·Nature Communications·Xia HuAiwen Lei
May 6, 2021·Organic & Biomolecular Chemistry·Chen LiZhen-Yuan Xu
Jun 25, 2021·Chemical Record : an Official Publication of the Chemical Society of Japan ... [et Al.]·Tanumay SarkarTharmalingam Punniyamurthy
May 24, 2019·The Journal of Organic Chemistry·Manoj KumarAkhilesh K Verma
Oct 27, 2017·The Journal of Organic Chemistry·Aniket MishraIndubhusan Deb
Jul 7, 2020·Organic Letters·You-Ke ChenYi Lu
Sep 11, 2019·The Journal of Organic Chemistry·Se Hun Kwak, Olafs Daugulis
Mar 13, 2020·The Journal of Organic Chemistry·Huu-Manh VuGuo-Qing Shi

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