Ligand-regulated oligomerisation of allosterically interacting proteins

Soft Matter
Charley SchaeferTom C B McLeish

Abstract

The binding of ligands to distinct sites at proteins or at protein clusters is often cooperative or anti-cooperative due to allosteric signalling between those sites. The allostery is usually attributed to a configurational change of the proteins from a relaxed to a configurationally different tense state. Alternatively, as originally proposed by Cooper and Dryden, a tense state may be achieved by merely restricting the thermal vibrations of the protein around its mean configuration. In this work, we provide theoretical tools to investigate fluctuation allostery using cooling and titration experiments in which ligands regulate dimerisation, or ring or chain formation. We discuss in detail how ligands may regulate the supramolecular (co)polymerisation of liganded and unliganded proteins.

References

Jan 1, 1984·European Biophysics Journal : EBJ·A Cooper, D T Dryden
Jul 8, 2000·Trends in Cell Biology·D Chin, A R Means
Oct 11, 2001·Proceedings of the National Academy of Sciences of the United States of America·A AggeliN Boden
Mar 27, 2003·Journal of the American Chemical Society·Sutjano JusufPaul H Axelsen
Sep 28, 2004·Physical Review Letters·Rhoda J Hawkins, Tom C B McLeish
Jun 4, 2005·Science·Jean-Pierre Changeux, Stuart J Edelstein
Jun 27, 2006·Biophysical Journal·Rhoda J Hawkins, Tom C B McLeish
Aug 15, 2006·Nature Structural & Molecular Biology·Nataliya PopovychCharalampos G Kalodimos
Jul 20, 2007·Nature·Kendra King FrederickA Joshua Wand
Apr 11, 2009·Science·Robert G Smock, Lila M Gierasch
Sep 23, 2009·Chemical Reviews·Tom F A De GreefE W Meijer
Dec 18, 2009·Journal of the American Chemical Society·Maarten M J SmuldersE W Meijer
Apr 13, 2010·Nature Chemical Biology·Michael S MarlowA Joshua Wand
May 15, 2012·Annual Review of Biophysics·Vincent J HilserHesam N Motlagh
Aug 18, 2012·The Journal of Chemical Physics·S Jabbari-Farouji, Paul van der Schoot
Oct 9, 2013·Proceedings of the National Academy of Sciences of the United States of America·Peter A KorevaarE W Meijer
Apr 18, 2014·Nature·Hesam N MotlaghVincent J Hilser
Mar 5, 2015·Chemical Society Reviews·Christina RestGustavo Fernández
Mar 17, 2016·The Journal of Chemical Physics·Prithviraj Nandigrami, John J Portman
May 10, 2017·Journal of the American Chemical Society·Anindita DasE W Meijer
Jul 12, 2017·Accounts of Chemical Research·Chidambar KulkarniAnja R A Palmans
May 8, 2018·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Tom McLeishA C von der Heydt

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