PMID: 6988695Feb 8, 1980Paper

Ligandin: an adventure in liverland

Molecular and Cellular Biochemistry
I M AriasI Listowsky

Abstract

Ligandin is an abundant soluble protein which has a t 1/2 of 2--3 days, is induced by many drugs and chemicals, and is stabilized in the absence of thyroid hormone. The protein is strategically concentrated in cells associated with transport and detoxification of many endogenous ligands, such as bilirubin, and exogenous ligands, such as drugs and chemicals. The protein is a dimer in rat liver. Whether the dimer is a primary gene product or at least two genes are involved is not known. The protein has broad, low affinity catalytic activity as a GSH-S-transferase for many ligands having electrophilic groups and hydrophobic domains. It catalyzes formation of GSH conjugates, non-covalently binds some ligands prior to their biotransformation or excretion in bile, and covalently binds other ligands, such as activated carcinogens. Recent studies include the possible role of ligandin in chemical carcinogenesis, diagnosis of inflammatory and neoplastic disease of the liver and kidney, and participation in intracellular transport. Although some of the roles that have been outlined are speculative, any single function is important. The GSH-S-transferases are primitive enzymes and non-specific binding proteins but "it is precisely their si...Continue Reading

Citations

Jan 1, 1985·The International Journal of Biochemistry·J F Glatz, J H Veerkamp
Jan 1, 1985·Comparative Biochemistry and Physiology. B, Comparative Biochemistry·Y C Awasthi, S V Singh
Oct 22, 2002·Molecular and Biochemical Parasitology·Eva LiebauRolf D Walter
Feb 26, 2003·Neurobiology of Aging·Esther Martínez-LaraM Angeles Peinado
Feb 8, 2011·Analytical Biochemistry·Natalia Fedulova, Bengt Mannervik
Jun 19, 2013·Cell·Akiko KumagaiAtsushi Miyawaki
Apr 30, 1984·Biochemical and Biophysical Research Communications·M DasH Mukhtar
Dec 3, 2020·Drug Metabolism Reviews·Philip G Board, M W Anders
Dec 22, 2010·Archives of Biochemistry and Biophysics·Natalia FedulovaBengt Mannervik

Related Concepts

Metazoa
Tumor Promoters
Yb-Glutathione-S-Transferase
Immunoassay Method
Structure of Intestinal Gland
Intestines, Small
Alloenzymes
Kidney
Malignant Neoplasm of Kidney
Liver

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