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Ligands for glaucoma-associated myocilin discovered by a generic binding assay

ACS Chemical Biology

Nov 28, 2013

Susan D OrwigRaquel L Lieberman

Abstract

Mutations in the olfactomedin domain of myocilin (myoc-OLF) are the strongest link to inherited primary open angle glaucoma. In this recently identified protein misfolding disorder, aggregation-prone disease variants of myocilin hasten glaucoma-associated elevation of intraocular pressu...read more

Mentioned in this Paper

Study
CARS
Derivatives
APP protein, human
Pathogenic Organism
Structure-Activity Relationship
Protoplasm
Aggregation
Tertiary Protein Structure
Cell Culture Techniques
1
10
24
Paper Details
References
  • References30
  • Citations5
123

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Ligands for glaucoma-associated myocilin discovered by a generic binding assay

ACS Chemical Biology

Nov 28, 2013

Susan D OrwigRaquel L Lieberman

PMID: 24279319

DOI: 10.1021/cb4007776

Abstract

Mutations in the olfactomedin domain of myocilin (myoc-OLF) are the strongest link to inherited primary open angle glaucoma. In this recently identified protein misfolding disorder, aggregation-prone disease variants of myocilin hasten glaucoma-associated elevation of intraocular pressu...read more

Mentioned in this Paper

Study
CARS
Derivatives
APP protein, human
Pathogenic Organism
Structure-Activity Relationship
Protoplasm
Aggregation
Tertiary Protein Structure
Cell Culture Techniques
1
10
24

Related Papers

Paper Details
References
  • References30
  • Citations5
123
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