PMID: 8598679Feb 1, 1996Paper

Ligation-induced acute pancreatitis increases pancreatic circulating trypsinogen activation peptides

The Journal of Surgical Research
L T MerriamR J Joehl

Abstract

Ligation of the common bile-pancreatic duct induces hyperamylasemia and acute pancreatitis in rats. Pancreatic morphologic changes include edema, acinar cell damage, and mild inflammation. The pathogenesis of acute pancreatitis in this model is not understood, but may involve altered secretion and intrapancreatic activation of acinar proteases. We hypothesized that trypsinogen activation, measured by the production of plasma and pancreatic trypsinogen activation peptides (TAP), occurs early in this model. We performed the following experiments: rats were prepared with (1) bile-pancreatic ducts ligated and (2) ducts dissected but not ligated (sham). Rats were killed after 6, 24, and 48 hr. Serum amylase was measured and histologic sections were analyzed for morphologic changes. TAP was measured in both serum and pancreatic tissue homogenates using a specific polyclonal. anti-TAP antibody in an enzyme-linked immunosorbant assay. After 6, 24, and 48 hr of bile-pancreatic duct ligation, hyperamylasemia and acute morphologic changes of acute pancreatitis were observed. Evidence of acinar cell destruction was not evident until 48 hr after ligation. Levels of serum and pancreatic tissue TAP were significantly elevated at both 24 and 4...Continue Reading

Citations

Apr 10, 1997·Human Gene Therapy·S J McClaneS E Raper
Nov 19, 2005·American Journal of Physiology. Gastrointestinal and Liver Physiology·Taiichi OtaniMasatoshi Makuuchi
Jan 29, 2003·Anesthesiology·Louis P Vera-PortocarreroKarin N Westlund
Jul 29, 1999·The Journal of Surgical Research·P KruseE Hage

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