Ligature induced peri-implantitis: tissue destruction and inflammatory progression in a murine model

Clinical Oral Implants Research
Trang N Nguyen VoShohei Kasugai

Abstract

The aim of this study was to investigate tissue destruction and inflammatory progression of ligature-induced peri-implantitis in mice and to establish an alternative murine model of peri-implantitis. Sixty male C57BL/6NCrSlc mice (4-week-old) were used and the maxillary right first molars were extracted. Eight weeks after extraction, custom-made pure titanium machined screw type implants (0.8 × 1.5 mm) were placed, one implant per animal. Four weeks later, 5-0 silk ligatures were applied around implant necks to induce peri-implantitis. Animals were sacrificed at 0 (before ligature), 7, 14, 21 and 28 days after ligature. Half of the samples were analyzed radiologically and histologically to measure bone level change, osteoclast number, density, and distribution. The rest of the samples was used to determine the relative mRNA expression levels of IL-1 and TNF-α with RT-PCR analysis. Bone levels at all sites (buccal, palatal, mesial, distal) decreased 40-50% significantly 28 days after ligature (P < 0.01). Osteoclast number at all post-ligature time points increased significantly (P < 0.05). However, their density at day 28 decreased significantly compared to that of day 21 (P < 0.05). Accordingly, IL-1 and TNF-α mRNA expression i...Continue Reading

References

Mar 1, 1992·Clinical Oral Implants Research·J LindheC Marinello
Apr 1, 1991·Clinical Oral Implants Research·T BerglundhP Thomsen
May 1, 1994·Journal of Periodontology·B S Michalowicz
Mar 14, 1998·Journal of Prosthodontics : Official Journal of the American College of Prosthodontists·D A CurtisL Franz
Feb 1, 1994·Periodontology 2000·T O AlbrektssonL Sennerby
Aug 15, 2002·Clinical Oral Implants Research·Margareta HultinBjörn Klinge
Jul 23, 2003·Development·Céline ColnotJill A Helms
Apr 17, 2004·Journal of Clinical Periodontology·Tord BerglundhJan Lindhe
Aug 16, 2006·Clinical Oral Implants Research·Marja L LaineStefan Renvert
Mar 6, 2007·European Cells & Materials·A I PearceS G Pearce
Sep 9, 2008·Journal of Clinical Periodontology·Jan LindheUNKNOWN Group D of European Workshop on Periodontology
Sep 9, 2008·Journal of Clinical Periodontology·Nicola U Zitzmann, Tord Berglundh
Feb 4, 2009·Journal of Periodontology·Poliana Mendes DuarteFrancisco Humberto Nociti
Mar 24, 2009·Clinical Oral Implants Research·Poliana Mendes DuarteFrancisco Humberto Nociti Júnior
Aug 12, 2009·Proceedings of the National Academy of Sciences of the United States of America·Etsuko IkedaTakashi Tsuji
Nov 26, 2009·Archives of Oral Biology·Poliana Mendes DuarteMarta Ferreira Bastos
Jul 20, 2010·Clinical Oral Implants Research·Pierre SimonisHenri Tenenbaum
Jul 27, 2010·Journal of Clinical Periodontology·Gaudy L Torres de HeensUbele van der Velden
Mar 1, 2011·Journal of Clinical Periodontology·Niklaus P LangUNKNOWN Working Group 4 of Seventh European Workshop on Periodontology
Feb 19, 2011·Journal of Biomedicine & Biotechnology·Helieh S Oz, David A Puleo
Nov 29, 2012·Journal of Investigative and Clinical Dentistry·Rafael Scaf de MolonJoni Augusto Cirelli
Jan 26, 2013·The Journal of Craniofacial Surgery·Stephan T BeckerJörg Wiltfang
Apr 27, 2013·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·Stefan Stübinger, Michel Dard
May 16, 2013·Journal of Immunological Methods·Toshiharu Abe, George Hajishengallis
Aug 28, 2013·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·Orlando MartinsMichel M Dard
Oct 24, 2013·BioMed Research International·Rayyan A Kayal
Jan 7, 2014·The International Journal of Prosthodontics·Paolo PescePaolo Pera
Jan 21, 2014·Clinical Oral Implants Research·Fabrizio SgolastraAnnalisa Monaco
Apr 2, 2014·Clinical Oral Implants Research·Gerardo Gómez-MorenoJosé Luis Calvo-Guirado
May 23, 2014·Implant Dentistry·Alina E PârvuSandu F Alb
Jun 27, 2014·The Journal of Oral Implantology·Flavia Q PirihPaulo M Camargo
Sep 23, 2014·Journal of Periodontal Research·F Q PirihP M Camargo
Sep 27, 2014·British Dental Journal·A AlaniK Bishop
Sep 28, 2014·Journal of Dental Research·O Carcuac, T Berglundh
Dec 24, 2014·Nature Reviews. Immunology·George Hajishengallis
Mar 21, 2015·World Journal of Orthopedics·Gabriela GiroJamil Awad Shibli
Apr 14, 2015·Periodontology 2000·Frank SchwarzMartin Sager
May 1, 1994·Journal of Periodontology·Bryan S Michalowicz

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Citations

Sep 19, 2017·Journal of Clinical Periodontology·Sarah HiyariFlavia Q Pirih
Mar 10, 2018·Journal of Periodontology·Ryan L WongFlavia Q Pirih
Oct 25, 2017·The Journal of Oral Implantology·Ryan L WongFlavia Q Pirih
May 19, 2019·Clinical Oral Investigations·Ronaldo Lira-JuniorElisabeth A Boström
Oct 19, 2017·Journal of Periodontal Research·S HiyariF Q Pirih
Dec 20, 2019·Journal of Prosthodontic Research·Seiya YamazakiRyuji Hosokawa
Aug 21, 2019·Journal of Clinical Medicine·David ReinedahlAnn Wennerberg
Jan 26, 2021·IScience·João Gabriel Silva SouzaValentim Adelino Ricardo Barão

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