PMID: 11920710Mar 29, 2002Paper

Light- and electron-microscopic analysis of vasoactive intestinal polypeptide-immunoreactive amacrine cells in the guinea pig retina

The Journal of Comparative Neurology
Eun-Jin LeeMyung-Hoon Chun

Abstract

Vasoactive intestinal polypeptide (VIP) is a neuroactive substance that is expressed in both nonmammalian and mammalian retinas. This study investigated the morphology and synaptic connections of VIP-containing neurons in the guinea pig retina by immunocytochemistry, by using antisera against VIP. Specific VIP immunoreactivity was localized to a population of wide-field and regularly spaced amacrine cells with processes ramifying mainly in strata 1 and 2 of the inner plexiform layer (IPL). Double-label immunohistochemistry demonstrated that all VIP-immunoreactive cells possessed gamma-aminobutyric acid immunoreactivity. The synaptic connectivity of VIP-immunoreactive amacrine cells was identified in the IPL by electron microscopy. The VIP-labeled amacrine cell processes received synaptic input from other amacrine cell processes and bipolar cell axon terminals in strata 1 to 3 of the IPL. The most frequent postsynaptic targets of VIP-immunoreactive amacrine cells were other amacrine cell processes in strata 1 to 3 of the IPL. Synaptic outputs to bipolar cells were also observed in strata 1 to 3 of the IPL. In addition, ganglion cell dendrites were also postsynaptic to VIP-immunoreactive neurons in the sublamina a of the IPL. The...Continue Reading

References

Mar 22, 1978·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·H Wässle, H J Riemann
Jan 1, 1992·Progress in Brain Research·N C Brecha
Oct 8, 1991·The Journal of Comparative Neurology·M Lammerding-KöppelW Koehler
Sep 22, 1989·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·D I VaneyH M Young
Dec 15, 1987·The Journal of Comparative Neurology·M A FreedP Sterling
Oct 4, 1974·Science·H Kolb, E V Famiglietti
Jan 1, 1982·Histochemistry·K TornqvistB Ehinger
Apr 1, 1981·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·S M HsuH Fanger
Jun 22, 1993·The Journal of Comparative Neurology·M H ChunH Wässle
May 1, 1993·Visual Neuroscience·U GreferathP Seeburg
Oct 23, 1995·The Journal of Comparative Neurology·T Euler, H Wässle
Apr 4, 1998·Brain Research. Molecular Brain Research·V D'Agata, S Cavallaro

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Citations

Oct 24, 2003·The Journal of Comparative Neurology·Alessandro CellerinoKonrad Kohler
Nov 1, 2006·The European Journal of Neuroscience·Eun-Jin LeeNorberto M Grzywacz
May 5, 2017·The Journal of Comparative Neurology·Luis Pérez de Sevilla MüllerNicholas C Brecha
Jun 14, 2005·The Journal of Comparative Neurology·Tae-Hoon KangMyung-Hoon Chun
Aug 28, 2015·Journal of Neurophysiology·Alejandro Akrouh, Daniel Kerschensteiner

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