Light- and electron-microscopic study of substance P-immunoreactive neurons in the guinea pig retina

Cell and Tissue Research
M Y LeeJ W Chung

Abstract

Substance P (SP) immunoreactivity in the guinea pig retina was studied by light and electron microscopy. The morphology and distribution of SP-immunoreactive neurons was defined by light microscopy. The SP-immunoreactive neurons formed one population of amacrine cells whose cell bodies were located in the proximal row of the inner nuclear layer. A single dendrite emerged from each soma and descended through the inner plexiform layer toward the ganglion cell layer. SP-immunoreactive processes ramified mainly in strata 4 and 5 of the inner plexiform layer. SP-immunoreactive amacrine cells were present at a higher density in the central region around the optic nerve head and at a lower density in the peripheral region of the retina. The synaptic connectivity of SP-immunoreactive amacrine cells was identified by electron microscopy. SP-labeled amacrine cell processes received synaptic inputs from other amacrine cell processes in all strata of the inner plexiform layer and from bipolar cell axon terminals in sublamina b of the same layer. The most frequent postsynaptic targets of SP-immunoreactive amacrine cells were the somata of ganglion cells and their dendrites in sublamina b of the inner plexiform layer. Amacrine cell processes...Continue Reading

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Citations

Jan 18, 2005·Experimental Eye Research·Michelle Loeliger, Sandra Rees
Aug 22, 2001·Microscopy Research and Technique·E A Debski
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Apr 6, 2007·Journal of Neural Engineering·Ali BashashatiGary E Birch
Apr 7, 2006·Visual Neuroscience·Olivia N DumitrescuHeinz Wässle

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