Light-activated nanotube-porphyrin conjugates as effective antiviral agents

Nanotechnology
I BanerjeeRavi S Kane

Abstract

Porphyrins have been used for photodynamic therapy (PDT) against a wide range of targets like bacteria, viruses and tumor cells. In this work, we report porphyrin-conjugated multi-walled carbon nanotubes (NT-P) as potent antiviral agents. Specifically, we used Protoporphyrin IX (PPIX), which we attached to acid-functionalized multi-walled carbon nanotubes (MWNTs). We decided to use carbon nanotubes as scaffolds because of their ease of recovery from a solution through filtration. In the presence of visible light, NT-P was found to significantly reduce the ability of Influenza A virus to infect mammalian cells. NT-P may be used effectively against influenza viruses with little or no chance of them developing resistance to the treatment. Furthermore, NT-P can be easily recovered through filtration which offers a facile strategy to reuse the active porphyrin moiety to its fullest extent. Thus NT-P conjugates represent a new approach for preparing ex vivo reusable antiviral agents.

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Citations

Nov 29, 2012·Applied Microbiology and Biotechnology·Navdeep GroverJonathan S Dordick
May 17, 2014·Current Opinion in Biotechnology·Ruchir V MundraRavi S Kane
Aug 29, 2012·Journal of Applied Microbiology·I BanerjeeR S Kane
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Apr 10, 2021·Photodiagnosis and Photodynamic Therapy·Mohammed Ali DheyabHawraa Ali Khaleel

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