Light adaptation controls visual sensitivity by adjusting the speed and gain of the response to light

PloS One
Andrew T RiderAndrew Stockman

Abstract

The range of c. 1012 ambient light levels to which we can be exposed massively exceeds the <103 response range of neurons in the visual system, but we can see well in dim starlight and bright sunlight. This remarkable ability is achieved largely by a speeding up of the visual response as light levels increase, causing characteristic changes in our sensitivity to different rates of flicker. Here, we account for over 65 years of flicker-sensitivity measurements with an elegantly-simple, physiologically-relevant model built from first-order low-pass filters and subtractive inhibition. There are only two intensity-dependent model parameters: one adjusts the speed of the visual response by shortening the time constants of some of the filters in the direct cascade as well as those in the inhibitory stages; the other parameter adjusts the overall gain at higher light levels. After reviewing the physiological literature, we associate the variable gain and three of the variable-speed filters with biochemical processes in cone photoreceptors, and a further variable-speed filter with processes in ganglion cells. The variable-speed but fixed-strength subtractive inhibition is most likely associated with lateral connections in the retina. A...Continue Reading

References

Jan 1, 1978·Annual Review of Psychology·D I MacLeod
Jan 1, 1978·Vision Research·W S Geisler
Jan 1, 1978·Vision Research·J K Bowmaker, G R Martin
Aug 1, 1976·The Journal of Physiology·H B Barlow, W R Levick
Jun 1, 1975·The Journal of Physiology·C Enroth-Cugell, P Lennie
Jun 1, 1975·The Journal of Physiology·C Enroth-CugellR M Shapley
Apr 1, 1992·Vision Research·N Graham, D C Hood
Jul 1, 1992·Vision Research·N Graham, D C Hood
Jun 1, 1992·Vision Research·E E Hartmann, M S Banks
Dec 1, 1990·Journal of the Optical Society of America. A, Optics and Image Science·B B LeeA Valberg
Aug 1, 1990·The Journal of Physiology·J L SchnapfD A Baylor
Apr 1, 1989·Kidney International·R A Koene
Oct 1, 1987·Journal of the Optical Society of America. A, Optics and Image Science·W H SwansonJ Pokorny
Dec 1, 1987·The Journal of Physiology·B ChenA Stockman
Mar 1, 1985·Journal of the Optical Society of America. A, Optics and Image Science·C W Tyler
Nov 1, 1974·The Journal of Physiology·D A Baylor, A L Hodgkin
May 1, 1972·Vision Research·B J Rogers, S M Anstis
Dec 1, 1969·Journal of the Optical Society of America·D H Kelly
Aug 1, 1968·Journal of the Optical Society of America·G Sperling, M M Sondhi
Jun 1, 1968·Vision Research·W A Rushton, G H Henry
Jul 1, 1984·Nature·D TranchinaR M Shapley
Jan 1, 1983·Vision Research·J M Valeton, D van Norren
Jan 21, 1993·Nature·D I MacLeod, S He
Nov 1, 1995·Vision Research·T E von WiegandN Graham
Mar 13, 1998·Annual Review of Psychology·D C Hood
Apr 16, 1998·Vision Research·V Manahilov
Oct 26, 1999·Trends in Neurosciences·L T Sharpe, A Stockman
Apr 1, 1961·Journal of the Optical Society of America·D H KELLY
Aug 1, 1964·The Journal of Physiology·M G FUORTES, A L HODGKIN
Jan 1, 1962·Journal of the Optical Society of America·D H KELLY
Jan 31, 2006·Journal of Vision·Orin S Packer, Dennis M Dacey
Jan 11, 2007·Journal of Vision·Andrew StockmanLindsay T Sharpe
Apr 28, 2007·Journal of Vision·J H van Hateren, H P Snippe

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Jul 31, 2021·The Journal of Experimental Biology·Kristian Donner

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