Light and electron microscopic identification of monoaminergic terminals in the central nervous system
A brief critical survey of methods used for light and electron microscopic examination of amine-containing pathways within the CNS. Light microscopic techniques such as fluorescence histochemistry, immunocytochemistry, autoradiography, silver degeneration techniques, and retrograde tracing technique are suitable for studying the topography of pathways but, due to limits of resolution, they are inadequate for identifying terminals. Electron microscopy which is adequate to visualize terminals does not provide an overall view. This review considers various methods which have been devised to specifically detect aminergic nerve terminals. Electrolytic and chemical induced degenerations are described in noradrenergic, dopaminergic, and serotoninergic terminals. Although the individual degenerative alterations are not specific for aminergic terminals, the degenerative process when considered as a whole can be informative. At present no single technique can provide complete information about the origin, course, connections, and terminals of aminergic systems. Concurrent application of light and electron microscopy, experimental surgery, histochemistry, and microsample biochemistry would provide a complete description.
Differential projections of the nucleus raphe dorsalis and nucleus raphe centralis as revealed by autoradiography
Ascending projections of the locus coeruleus in the rat. I. Axonal transport in central noradrenaline neurons
Radioautographic identification of serotonin axon terminals in the rat organum vasculosum laminae terminalis
The topographical distribution of serotoninergic terminals in the spinal cord of the cat: quantitative radioautographic studies
An autoradiographic analysis of the differential ascending projections of the dorsal and median raphe nuclei in the rat
Ultrastructural evidence for central monoaminergic innervation of blood vessels in the paraventricular nucleus of the hypothalamus
The bulbospinal monoaminergic system of the chick: degeneration in the sympathetic nucleus following surgical and chemical lesions
Ultrastructural identification of noradrenergic terminals in rat hippocampus: unilateral destruction of the locus coeruleus with 6-hydroxydopamine
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Ultrastructure of the serotonergic nerve terminals in the suprachiasmatic and interpeduncular nuclei of rat brains
The origin of the monoaminergic innervation of immature rat neocortex: an ultrastructural analysis following lesions
Serotonin axons in the supra- and subependymal plexuses and in the leptomeninges; their roles in local alterations of cerebrospinal fluid and vasomotor activity
The topographical distribution of serotoninergic terminals in the neostriatum of the rat and the caudate nucleus of the cat
Serotonergic innervation of the forebrain: effect of lesions on serotonin and tryptophan hydroxylase levels
Ultrastructural characterization of synaptosomes from neonatal and adult rats with special reference to monoamines
Autoradiographic evidence for the selective accumulation of [3H]5-HT by supra-ependymal nerve terminals
Electron microscopic evidence of direct neuronal connections from the lower brain stem to the median eminence
Silver impregnation of dopaminergic systems after radiofrequency and 6-OHDA lesions of the rat ventral
Radioautographic study of in vivo incorporation of 3H-monoamines in the cat caudate nucleus: identification of serotoninergic fibers
Brain tryptophan hydroxylase: purification of, production of antibodies to, and cellular and ultrastructural localization in serotonergic neurons of rat midbrain
Projections to the median eminence and the arcuate nucleus with special reference to monoamine systems: effects of lesions
Ultrastructural identification of noradrenergic boutons in mutant and normal mouse cerebellar cortex
Disappearance of supra-ependymal 5-HT axons in the rat forebrain after electrolytic and 5,6-DHT-induced lesions of the medial forebrain bundle
Light and electron microscopic autoradiography of substantia nigra of rat after intraventricular administration of tritium labelled norepinephrine, dopamine, serotonin and the precursors
Axonal transport in nigro-striatal and nigro-thalamic neurons: effects of medial forebrain bundle lesions and 6-hydroxydopamine
Ultrastructural identification of catecholamine neurones in the hypothalamic periventricular-arcuate nucleus-median eminence complex with special reference to quantitative aspects
Demonstration of the nigrostriatal projection by silver staining after nigral injections of 6-hydroxydopamine
Analysis of the fine structure of the dopaminergic nigrostriatal projection by electron microscopic autoradiography
Accumulation and axoplasmic transport of dopamine but not of amino acids by axons of the nigro-neostriatal projection
Selective degeneration of central dopaminergic systems after injection of 6-hydroxydopamine in the ventral mesencephalic tegmentum of the rat. Demonstration by the Fink-Heimer strain
Two methods for selective silver impregnation of degenerating axons and their synaptic endings in the central nervous system
Selective reduction of tryptophan hydroxylase activity in rat forebrain after midbrain raphe lesions
Ultrastructural evidence for the localization of an indolealkylamine in supra-ependymal nerves from combined cytochemistry and pharmacology
Organization and ultrastructural identification of the catecholamine nerve terminals in the neural lobe and pars intermedia of the rat pituitary
Neuronal degeneration in rat brain induced by 6-hydroxydopamine; a histological and biochemical study
Indolealkylamine nerve terminals in cerebral ventricles: identification by electron microscopy and fluorescence histochemistry
5-Hydroxydopamine 'tagged' neuronal boutons in rabbit neostriatum: interrelationship between vesicles and axonal membrane
Effect of 6-hydroxydopamine on hypothalamic norepinephrine and dopamine content, ultrastructure of the median eminence, and plasma corticosterone
The fine structural localization of norepinephrine- 3 H in the substantia nigra and area postrema of the rat. An autoradiographic study
Effects of lesions of locus coeruleus on regional distribution of dopamine-beta-hydroxylase activity in rat brain
Connections of the median and dorsal raphe nuclei in the rat: an autoradiographic and degeneration study
Ultrastructural and fluorescence histochemical studies on the effects of 6-hydroxydopamine on the rat median eminence
The use of dopamine -hydroxylase as a marker for the central noradrenergic nervous system in rat brain
5,7-dihydroxytryptamine: improvement in chemical lesioning of indoleamine neurons in the mammalian brain
Noradrenergic axon in the cerebral cortex of rat. I. Radioautographic visualization after topical application of DL-( 3 H)norepinephrine
Dynamic changes in brain dopamine-beta-hydroxylase activity during anterograde and retrograde reactions to injury of central noradrenergic axons
A fluorescence histochemical study of the degeneration and regeneration of noradrenergic nerves in the chick following treatment with 6-hydroxydopamine
Localization of tritiated dopamine in the median eminence of the rat hypothalamus by electron microscope autoradiography
An experimental investigation of the relationship between granular vesicles and noradrenergic axons in the preoptic area of the rat
Brain dopamine- -hydroxylase: regional distribution and effects of lesions and 6-hydroxy-dopamine on activity
Chemical degeneration of indolamine axons in rat brain by 5,6-dihydroxytryptamine. An ultrastructural study
Distribution of noradrenaline storing particles in peripheral adrenergic neurons as revealed by electron microscopy
The ultrastructural localisation of amine storage sites in the central nervous system with the aid of a specific marker, 5-hydroxydopamine
Electron microscopic studies of wallerian degeneration in rat optic nerves. II. Astrocytes, oligodendrocytes and adventitial cells
Mode of termination of primary vestibular fibres in the lateral vestibular nucleus. An experimental electron microscopical study in the cat
A comparison of the mode of termination of the hippocampal and hypothalamic afferents to the septal nuclei as revealed by electron microscopy of degeneration
Electronmicroscopic localization of 5-hydroxydopamine (3,4,5-trihydroxy-phenyl-ethylamine), a new 'false' sympathetic transmitter
EVIDENCE FOR THE EXISTENCE OF MONOAMINE NEURONS IN THE CENTRAL NERVOUS SYSTEM. 3. THE MONOAMINE NERVE TERMINAL
Mapping of transmitter-specific connections: simultaneous demonstration of anterograde degeneration and changes in the immunostaining pattern induced by lesions
Fluorescence microscopy used in conjunction with horseradish peroxidase localization and electron microscopy for studying sympathetic nuclei of the rat spinal cord
Segregation of the intra- and extrahypothalamic neuropeptide Y and catecholaminergic inputs on paraventricular neurons, including those producing thyrotropin-releasing hormone
Luteinizing hormone-releasing hormone and gamma-aminobutyric acid neurons in the medial preoptic area are synaptic targets of dopamine axons originating in anterior periventricular areas
Corticosterone-dependent alterations in utilization of catecholamines in discrete areas of rat brain
Hypothalamic self-stimulation in rats with one hemisphere isolated anterior to the midbrain and the other hemisphere devoid of the telencephalon
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