Light and electron microscopic study of the effects of ZnSO4 on mouse nasal respiratory epithelium and subsequent responses.

The Anatomical Record
D H Matulionis

Abstract

The effects of ZnSO4 irrigation on mouse nasal respiratory epithelium (NRE) and subsequent responses of the tissue were studied at the light and electron microscopic levels in two different strains of mice (C57Bl/6J and SWR/J). The most marked effect of the ZnSO4 took the form of necrosis and sloughing of surface cells in both strains one-half day after ZnSO4 irrigation. This treatment caused maximal change in a different cell type in each of the two strains. Ciliated cells were most noticeably affected in the C57Bl/6J strain, secretory cells in the SWR/J strain. Subsequent manifestations of recovery differed accordingly in each strain. In the C57Bl/6J mice numerous dividing surface cells and large areas of tall nonciliated and ciliating cells were prominent two to five days after treatment. Secretory cells appeared normal but were reduced in numbers during this time, indicating that they were also affected by the treatment. The NRE of this strain was normal by the fourteenth day following treatment. The NRE of SWR/J animals, on the other hand, contained no visibly dividing cells and no large areas of nonciliated cells during the first four days following treatment, although a few ciliating cells were present at this time. The ...Continue Reading

References

Jan 1, 1970·The Anatomical Record·B L Shapiro
May 1, 1973·The Anatomical Record·D H Matulionis, H F Parks
Mar 1, 1974·The Annals of Otology, Rhinology, and Laryngology·D H Matulionis
Jan 1, 1972·The American Journal of Anatomy·D R Adams
Jun 1, 1971·The American Journal of Anatomy·B D Mulvaney, H E Heist
Oct 1, 1968·The Anatomical Record·D Frisch, A I Farbman
Jul 1, 1967·The American Journal of Anatomy·D Frisch

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Citations

Jan 1, 1986·Virchows Archiv. A, Pathological Anatomy and Histopathology·D H Matulionis
Jan 1, 1988·Virchows Archiv. A, Pathological Anatomy and Histopathology·D H Matulionis, R A Yokel
Jan 1, 1979·Neuroscience and Biobehavioral Reviews·C J Wysocki
Aug 26, 2000·Behavioral Neuroscience·B SlotnickN Bodyak
Jan 1, 1983·Virchows Archiv. B, Cell Pathology Including Molecular Pathology·K P KeenanE M McDowell
Oct 17, 2012·The Laryngoscope·Merrill A BielNicolas Loebel
May 12, 2007·The Journal of Comparative Neurology·Ali JahedMichael D Kawaja

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