Light and ultrastructural study in the propylthiouracil-induced hypothyroid rat heart ventricles and the ameliorating role of folic acid

Toxicology and Industrial Health
Ahmed A MassoudHeba Abou-Harga

Abstract

Thyroid hormones have marked effects on the growth, development, and metabolic function of virtually all organs and tissues. Thyroid status is an important determinant of cardiovascular function. The present work studied the histopathological and ultrastructural changes in the hypothyroid rat left ventricle at post-pubertal stage, in addition to the ameliorating role of folic acid. A total of 50 male albino rats were randomly divided into 5 groups (group I, control; group II, folic acid; group III, propylthiouracil-induced hypothyroid rats; group IV, co-treatment with folic acid; group V, post-treatment). In order to ensure the hypothyroid state, the level of serum triiodothyronine (T(3)) and thyroid stimulating hormone (TSH) through the dose period was regularly determined. The TSH levels were significantly higher while T(3) levels were significantly lower in hypothyroid rats when compared to control group. The high-performance liquid chromatography analysis showed an increase in homocysteine (Hcy) in the hypothyroid rats group when compared to the control group. The histopathological studies of the ventricle in hypothyroid rats revealed hydrophobic changes in myofibrillar structure with striations, myocardial atrophy, nuclear...Continue Reading

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Citations

Feb 16, 2013·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Wafaa A HassanAsmaa S Shahat
Oct 24, 2012·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Ehab ToussonRana M Ashraf
Aug 9, 2020·Oxidative Medicine and Cellular Longevity·Maha A AldubayanRehab M Elgharabawy
Jan 31, 2020·Oxidative Medicine and Cellular Longevity·Xiaolei WangJiajun Zhao
Dec 14, 2018·The Journal of General Physiology·Jason J BreithauptBertrand C W Tanner

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