Light chain Fanconi syndrome in a patient with acute myeloid leukemia and monoclonal gammopathy of undetermined significance

CEN Case Reports
Daniel W RossKenar D Jhaveri

Abstract

Proximal tubules are a target for paraproteinemic diseases. Cast nephropathy, light chain deposition diseases, and amyloidosis are frequently encountered in patients with multiple myeloma. Rarely, a subset of patients develop light chain Fanconi syndrome (LCFS). LCFS has been reported with multiple myeloma, monoclonal gammopathy of renal significance (MGRS), chronic lymphocytic leukemia, Waldenstrom's macroglobulinemia and diffuse large B-cell lymphoma. No cases have been described with other hematologic malignancies. We report the first case of lambda LCFS in a patient with both acute myeloid leukemia (AML) and monoclonal gammopathy of undetermined significance (MGUS).

References

Mar 31, 2006·The New England Journal of Medicine·Robert A KyleL Joseph Melton
Sep 20, 2006·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Samar M SaidSamih H Nasr
Oct 12, 2010·Indian Journal of Medical and Paediatric Oncology : Official Journal of Indian Society of Medical & Paediatric Oncology·Aruna RanganTina Dadu
Jun 28, 2011·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Christopher P LarsenPatrick D Walker
Apr 5, 2012·International Journal of Laboratory Hematology·V H Jimenez-Zepeda

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