Light-driven transformable optical agent with adaptive functions for boosting cancer surgery outcomes

Nature Communications
Ji QiBen Zhong Tang

Abstract

Fluorescence and photoacoustic imaging have different advantages in cancer diagnosis; however, combining effects in one agent normally requires a trade-off as the mechanisms interfere. Here, based on rational molecular design, we introduce a smart organic nanoparticle whose absorbed excitation energy can be photo-switched to the pathway of thermal deactivation for photoacoustic imaging, or to allow opposed routes for fluorescence imaging and photodynamic therapy. The molecule is made of a dithienylethene (DTE) core with two surrounding 2-(1-(4-(1,2,2-triphenylvinyl)phenyl)ethylidene)malononitrile (TPECM) units (DTE-TPECM). The photosensitive molecule changes from a ring-closed, for photoacoustic imaging, to a ring-opened state for fluorescence and photodynamic effects upon an external light trigger. The nanoparticles' photoacoustic and fluorescence imaging properties demonstrate the advantage of the switch. The use of the nanoparticles improves the outcomes of in vivo cancer surgery using preoperative photoacoustic imaging and intraoperative fluorescent visualization/photodynamic therapy of residual tumours to ensure total tumour removal.

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Citations

Dec 18, 2018·Advanced Materials·Qinrui FuXiaoyuan Chen
Aug 10, 2019·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Lingchen MengWenjing Tian
Oct 4, 2019·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Xu Zhen, Xiqun Jiang
Aug 10, 2020·Chembiochem : a European Journal of Chemical Biology·Shichao Wang, Xuanjun Zhang
Oct 3, 2018·Advanced Materials·Mengyuan LiLele Li
Jul 4, 2018·Advanced Healthcare Materials·Ji QiBen Zhong Tang
Oct 5, 2018·Chemical Society Reviews·Wen LiXiaogang Qu
Sep 28, 2018·Chemical Society Reviews·Yijing LiuXiaoyuan Chen
Mar 20, 2019·Chemical Communications : Chem Comm·Yue WuWei-Hong Zhu
Apr 8, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Yaqi YangBen Zhong Tang
Mar 13, 2020·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Nicholas E Wojtynek, Aaron M Mohs
Sep 19, 2020·Biomaterials Science·Qingxiang GuoJianfeng Liu
Nov 17, 2020·Chemical Society Reviews·Guangxue FengDan Ding
Nov 15, 2020·Journal of Controlled Release : Official Journal of the Controlled Release Society·Hanieh MousazadehNosratollah Zarghami

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Methods Mentioned

BETA
imaging techniques
fluorescence imaging
nuclear magnetic resonance
X-ray
nanoprecipitation
transmission electron microscopy
xenograft
surgical resection
transgenic

Software Mentioned

GraphPad
GraphPad Prism

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