PMID: 16641531Apr 28, 2006Paper

Light-emitting diode phototherapy at 630 +/- 3 nm increases local levels of skin-homing T-cells in human subjects

Journal of Nippon Medical School = Nippon Ika Daigaku Zasshi
Shin-Ichiro TakezakiSeiji Kawana

Abstract

Red light phototherapy with laser sources has been used successfully for a number of indications. A new generation of quasimonochromatic 630 +/- 3 nm light-emitting diode (LED) systems has recently been yielding good results for the same indications, but no study has examined changes in visible red light irradiated skin at an immunological level. This study was thus designed to examine changes in skin-homing T-cell levels induced in normal human skin by visible red LED energy. Six adult male volunteers (35 approximately 48 years old) who satisfied all study criteria had the skin over the lateral aspect of the leg irradiated once per week for 8 weeks with a visible red (630 +/- 3 nm) LED-based system, with irradiance of 105 m/cm2, 15 minutes/session, and a radiant flux of 94 J/cm2. Skin biopsies were performed after the eighth treatment session, and cultures were prepared to assay the type and quantity of skin-homing T-cells using qualitative and quantitative polymerase chain reaction (PCR) techniques. Ultrastructural changes were also assessed with transmission electron microscopy. Transmission electron microscopy revealed mild fibroplastic changes in fibroblasts, with no acute inflammatory changes throughout the treatment sess...Continue Reading

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Citations

Oct 22, 2010·Photomedicine and Laser Surgery·Carlos A KelenczRenata A Nicolau
Jan 31, 2012·Photomedicine and Laser Surgery·Maria Emília de Abreu ChavesLeandro Soares Oliveira
Sep 10, 2010·Journal of Cosmetic and Laser Therapy : Official Publication of the European Society for Laser Dermatology·Tokuya OmiZenya Naito
Dec 14, 2011·Journal of Cosmetic Dermatology·Tokuya OmiZenya Naito

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