Light-emitting diodes at 830 and 850 nm inhibit melanin synthesis in vitro

Acta Dermato-venereologica
Jeong Mo KimAi-Young Lee

Abstract

Treatment of hyperpigmentation remains a challenge. Because of the positive effects of low-energy Nd:YAG lasers on the treatment of melasma, it is suggested that laser-like light-emitting diodes (LEDs) can potentially ameliorate hyperpigmentation. We evaluated the effect of seven different LED wavelengths on melanogenesis. LED irradiation at 830 nm (dose-dependent, from 1 to 20 J/cm2) and 850 nm (1 J/cm2) significantly reduced melanin production and tyrosinase expression, not only in a normal human melanocyte monoculture both with and without forskolin stimulation but also in a three-dimensional multiple cell type culture. It reduced melanin content via inactivation of the apoptosis signal-regulating kinase and extracellular signal-regulated kinase 1/2 pathways. The level of phosphorylated cyclic AMP response element-binding protein was also decreased by LED irradiation. Moreover, LED irradiation reduced melanogenesis through decreased expression of tyrosinase family genes (tyrosinase-related protein-1 and 2, and microphthalmia-associated transcription factor). These results indicate that LEDs could potentially be used to treat melanin-overproducing skin conditions.

Citations

Feb 19, 2015·Archives of Dermatological Research·Yu Ra JungMyung Im
Dec 29, 2015·International Journal of Cosmetic Science·A J Greaves
Jan 21, 2017·Annales de dermatologie et de vénéréologie·C NoéH Cartier
Sep 7, 2016·Journal of Cosmetic and Laser Therapy : Official Publication of the European Society for Laser Dermatology·Scott DunbarDavid J Goldberg
May 5, 2020·Technology and Health Care : Official Journal of the European Society for Engineering and Medicine·Mi Yeon ShinChang Ho Yu
Aug 25, 2020·Photobiomodulation, Photomedicine, and Laser Surgery·Steven Paul NisticòGiovanni Cannarozzo
Feb 16, 2021·Facial Plastic Surgery : FPS·Jose A De Cordova

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