Light-enhanced bacterial killing and wash-free imaging based on AIE fluorogen

ACS Applied Materials & Interfaces
Engui ZhaoBen Zhong Tang

Abstract

The rapid acquisition of antibiotic resistance poses difficulties in the development of effective methods to eliminate pathogenic bacteria. New bactericides, especially those do not induce the emergence of resistance, are thus in great demand. In this work, we report an aggregation-induced emission fluorogen, TPE-Bac, for bacterial imaging and elimination. TPE-Bac can be readily dissolved in aqueous solution with weak emission. The presence of bacteria can turn on its emission, and thus no washing step is required in the imaging process. Meanwhile, TPE-Bac can be applied as a bactericide for elimination of bacteria. The amphiphilic TPE-Bac bearing two long alkyl chains and two positively charged amines can intercalate into the membrane of bacteria, increase membrane permeability and lead to dark toxicity. The efficiency of bacteria killing is greatly enhanced under light irradiation. TPE-Bac can serve as a photosensitizer to induce reactive oxygen species (ROS) generation, which ensures the efficient killing of bacteria. The TPE-Bac-containing agar plates can be continuously used for bacteria killing by applying light to induce ROS generation.

References

Nov 18, 2000·Antimicrobial Agents and Chemotherapy·C R RovaldiP Spacciapoli
Sep 21, 2002·Chemical Communications : Chem Comm·J LuoB Z Tang
May 4, 2004·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Michael R Hamblin, Tayyaba Hasan
Oct 6, 2004·International Journal of Immunopathology and Pharmacology·T N Demidova, M R Hamblin
Mar 29, 2005·Antimicrobial Agents and Chemotherapy·T MaischC Abels
Oct 19, 2005·Langmuir : the ACS Journal of Surfaces and Colloids·Liangde LuDavid G Whitten
Dec 27, 2005·Antimicrobial Agents and Chemotherapy·George P Tegos, Michael R Hamblin
Jul 31, 2008·The Journal of Organic Chemistry·Ping YanLeslie M Loew
Aug 30, 2008·Langmuir : the ACS Journal of Surfaces and Colloids·Sireesha ChemburuDavid G Whitten
Feb 6, 2009·BMC Microbiology·Parjam S ZolfaghariMichael Wilson
Jul 15, 2009·Chemical Communications : Chem Comm·Yuning HongBen Zhong Tang
Jan 28, 2009·ACS Applied Materials & Interfaces·Thomas S CorbittKirk S Schanze
Oct 1, 2005·Nanotechnology·Jose Ruben MoronesMiguel Jose Yacaman
Jun 15, 2011·Advanced Materials·Yong YuBen Zhong Tang
Jul 30, 2011·Chemical Society Reviews·Yuning HongBen Zhong Tang
Nov 11, 2011·Journal of Photochemistry and Photobiology. B, Biology·Juliana P M L RolimLidiany K A Rodrigues
Nov 30, 2011·Nanomedicine·Sulbha K SharmaMichael R Hamblin
May 31, 2012·Journal of the American Chemical Society·Haibin ShiBin Liu
Jul 1, 2014·Advanced Materials·Ju MeiBen Zhong Tang

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Citations

Mar 24, 2016·Chemical Communications : Chem Comm·Xing WangDecheng Wu
Oct 23, 2015·Chemical Reviews·Ju MeiBen Zhong Tang
Sep 30, 2016·Chemistry : a European Journal·George Rajendra KumarPakkirisamy Thilagar
Mar 10, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Long ZhaoXiaohong Li
Jul 28, 2016·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Jin ZhouHao Wang
Nov 7, 2019·Proceedings of the National Academy of Sciences of the United States of America·Sijia GaoZhongwei Niu
Jan 17, 2020·ChemPlusChem·Eunbee ChoTaek Seung Lee
Oct 14, 2016·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Yuanhao WuHui Gao
Jun 27, 2019·Advanced Healthcare Materials·Qingyan JiaWei Huang
Aug 28, 2018·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Shuai ChenHui Gao
Jul 26, 2019·International Journal of Molecular Sciences·Lisa EliasÁngel Serrano-Aroca
Feb 16, 2021·Journal of Drug Targeting·Rashmi Kumari, Dhanya Sunil
Apr 10, 2021·Topics in Current Chemistry·Harini A Perera, Mingdi Yan
May 22, 2021·Advanced Healthcare Materials·Bingnan WangBen Zhong Tang
Aug 4, 2021·Advanced Healthcare Materials·Qinggele BorjihanYing-Wei Yang
Oct 29, 2019·Accounts of Chemical Research·Fan XiaXiaoding Lou
Nov 16, 2017·ACS Applied Materials & Interfaces·Ju MeiHe Tian

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