PMID: 8192Sep 3, 1976

Light-evoked release of glycine from cat and rabbit retina

Brain Research
B Ehinger, B Lindberg-Bauer

Abstract

The light-evoked release of [3H]glycine from retina in cat (in vivo) after pre-retinal perfusion and in rabbit (in vitro) after intravitreal injection was studied. The site of uptake of [3H]glycine into retina was checked by autoradiography and was found to be almost exclusively in a type of amacrine cells. If the retina loaded with [3H]glycine was stimulated by light flashes the release increased significantly in both in vivo and in vitro experiments. When the flashing light was exchanged for continuous light there was not change in the spontaneous efflux of radioactivity. Chromatographic experiments showed that the main part of the radioactivity released by light was glycine. The light-evoked release of glycine from retina was dependent on temperature and Ca2+. Low temperature (+2 to +4 degrees C) abolished the increased release. If Ca2+ was ommitted from the perfusion medium and EDTA was added there was no light-inducable change in the efflux of radioactivity in retinas loaded with [3H]valine. The present results, that light stimulation will release glycine from the retina both in vivo and in vitro, are further criterion for it as neurotransmitter.

References

Nov 1, 1974·Experimental Eye Research·A Bruun, B Ehinger
Nov 1, 1972·Journal of Neurochemistry·P J Roberts, J F Mitchell
Jul 19, 1972·Nature: New Biology·N G Bowery, D A Brown
Sep 14, 1973·Brain Research·M S Starr
Jun 29, 1971·Experimental Brain Research·D R CURTISG A Johnston
Jan 1, 1968·Experimental Brain Research·D R CURTISG A Johnston
Nov 1, 1965·Life Sciences·M H Aprison, R Werman
Sep 1, 1960·Journal of Neurochemistry·D R CURTIS, J C WATKINS

Citations

Jan 1, 1981·Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie. Albrecht Von Graefe's Archive for Clinical and Experimental Ophthalmology·B Ehinger
Jan 1, 1987·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·S HayasakaK Tada
Mar 1, 1978·Experimental Eye Research·B Bauer, B Ehinger
Jan 1, 1981·Vision Research·B BauerK Tornqvist
Jun 1, 1985·Urology·W GillettR Lee
Jun 1, 1978·Pharmacology, Biochemistry, and Behavior·E D BiglerD E Fleming
Jan 1, 1985·Pharmacology & Therapeutics·A Kahán
Jan 1, 1980·Neurochemistry International·M J Neal, S C Massey
Jan 1, 1987·Progress in Neurobiology·S C Massey, D A Redburn
Mar 31, 1987·Neuroscience Letters·J Jäger, H Wässle
Mar 29, 2001·Journal of Neuroscience Methods·J PálhalmiG Juhász
Aug 15, 1976·Journal of Molecular Biology·L CarlssonS Lövgren
Aug 23, 1991·Brain Research·M K BoelenI G Morgan
Jul 22, 1992·Proceedings. Biological Sciences·C L Zucker, B Ehinger
Sep 1, 1983·Journal of Neurochemistry·M A Yorek, A A Spector
Jan 1, 1992·Documenta Ophthalmologica. Advances in Ophthalmology·R A Crone
Aug 1, 1978·Neurochemical Research·A M López-ColoméH Pasantes-Morales
Oct 1, 1985·Acta Ophthalmologica·B BauerJ Waga

Related Concepts

Calcium
Felis catus
Edetic Acid, Sodium Salt
Glycine, Sodium Hydrogen Carbonate
Retina
Neurohormones

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