Light-induced ATP release from the lens.

Purinergic Signalling
Jesus Pintor

Abstract

The recent discovery of the photoreceptor melanopsin in lens epithelial cells has opened the possibility of modulating this protein by light stimulation. Experiments carried out on New Zealand white rabbits have demonstrated that the release of ATP from the lens to the aqueous humor can be reduced either when a yellow filter or a melanopsin antagonist is used. Compared to control (1.10 ± 0.15 μM ATP), the application of a yellow filter (λ465-480) reduced ATP in the aqueous humor 70%, while the melanopsin antagonist AA92593 reduced the presence of ATP 63% (n = 5), an effect which was also obtained with the PLC inhibitor U73122. These results indicate that when melanopsin is blocked either by the lack of light, a filter, or an antagonist, the extracellular presence of ATP is significantly reduced. This discovery may be relevant, on the one hand, because many ocular physiological processes are controlled by ATP and, on the other hand, because it is possible to stimulate ATP release with just light and without using any added substance.

References

Feb 21, 1998·Proceedings of the National Academy of Sciences of the United States of America·I ProvencioM D Rollag
Jun 17, 1998·Proceedings of the National Academy of Sciences of the United States of America·C H MitchellM M Civan
Dec 20, 2002·The Journal of Pharmacology and Experimental Therapeutics·Jesús PintorCharles H V Hoyle
Mar 3, 2009·Experimental Eye Research·Assumpta PeralJesús Pintor
Apr 19, 2011·Purinergic Signalling·Jesús Pintor
Sep 3, 2014·Physiology·Russel J ReiterAnnia Galano
Dec 5, 2016·Experimental Eye Research·Hanan Awad AlkoziJesus Pintor
Mar 3, 2017·Neurology·Alexander KsendzovskyIgnacio Provencio
Aug 6, 2018·Journal of Optometry·Jesús Pintor

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Citations

Jan 15, 2019·Current Eye Research·Victoria Eugenia LledóJesús Pintor
Mar 7, 2021·Biomolecules·Alejandro Martínez-ÁguilaGonzalo Carracedo

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