Light-induced biocidal action of conjugated polyelectrolytes supported on colloids

Langmuir : the ACS Journal of Surfaces and Colloids
Sireesha ChemburuDavid G Whitten

Abstract

A series of water soluble, cationic conjugated polyelectrolytes (CPEs) with backbones based on a poly(phenylene ethynylene) repeat unit structure and tetraakylammonium side groups exhibit a profound light-induced biocidal effect. The present study examines the biocidal activity of the CPEs, correlating this activity with the photophysical properties of the polymers. The photophysical properties of the CPEs are studied in solution, and the results demonstrate that direct excitation produces a triplet excited-state in moderate yield, and the triplet is shown to be effective at sensitizing the production of singlet oxygen. Using the polymers in a format where they are physisorbed or covalently grafted to the surface of colloidal silica particles (5 and 30 microm diameter), we demonstrate that they exhibit light-activated biocidal activity, effectively killing Cobetia marina and Pseudomonas aeruginosa. The light-induced biocidal activity is also correlated with a requirement for oxygen suggesting that interfacial generation of singlet oxygen is the crucial step in the light-induced biocidal activity.

References

May 1, 1990·Journal of Photochemistry and Photobiology. B, Biology·Z MalikY Nitzan
Apr 2, 1999·Applied and Environmental Microbiology·L K IstaG P López
Oct 6, 2000·Journal of Applied Microbiology·T Hamouda, J R Baker
May 17, 2001·Proceedings of the National Academy of Sciences of the United States of America·J C TillerA M Klibanov
Jul 18, 2002·Chemical Communications : Chem Comm·Chunyan TanKirk S Schanze
Feb 26, 2003·Proceedings of the National Academy of Sciences of the United States of America·Bernard M BabiorPaul Wentworth
May 20, 2003·Journal of Applied Microbiology·M D JohnstonR J W Lambert
Sep 5, 2003·Journal of Medicinal Chemistry·Thorsteinn ThorsteinssonThorsteinn Loftsson
Oct 14, 2004·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Tim MaischChristoph Abels
Oct 21, 2004·Journal of the American Chemical Society·Chunyan TanKirk S Schanze
Jan 26, 2005·Zeitschrift Für Naturforschung. C, a Journal of Biosciences·Edyta WoźniakMagdalena Petryna
Jun 1, 2005·Trends in Biotechnology·Kim Lewis, Alexander M Klibanov
Oct 19, 2005·Langmuir : the ACS Journal of Surfaces and Colloids·Liangde LuDavid G Whitten
Mar 7, 2006·Applied and Environmental Microbiology·Ehud BaninE Peter Greenberg
Apr 28, 2006·Antimicrobial Agents and Chemotherapy·Dong H Kwon, Chung-Dar Lu
Jul 6, 2006·Applied and Environmental Microbiology·H-L AlakomiM Saarela
Sep 8, 2006·The Journal of Physical Chemistry. B·Alison M FunstonJohn R Miller
Mar 9, 2007·Langmuir : the ACS Journal of Surfaces and Colloids·Katsu OgawaKirk S Schanze
Mar 29, 2007·Langmuir : the ACS Journal of Surfaces and Colloids·Pinar KurtKenneth J Wynne
Apr 14, 2007·Proceedings of the National Academy of Sciences of the United States of America·Tim MaischWolfgang Bäumler
Apr 25, 2007·Journal of Fluorescence·Takashi Tachikawa, Tetsuro Majima
Jul 31, 2007·Langmuir : the ACS Journal of Surfaces and Colloids·Seoktae KangMenachem Elimelech
Aug 19, 2007·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Thomas BjarnsholtMichael Givskov
Aug 28, 2007·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Sean MathaiKenneth P Ghiggino
Feb 28, 2008·Langmuir : the ACS Journal of Surfaces and Colloids·Reema ZeineldinGabriel P Lopez
Apr 4, 2008·Organic & Biomolecular Chemistry·Justin J RichardsChristian Melander

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Citations

Sep 18, 2013·ACS Applied Materials & Interfaces·Qian YuGabriel P López
Oct 10, 2013·ACS Applied Materials & Interfaces·Kristin N WildeHeather E Canavan
Jun 8, 2012·Chemical Reviews·Chunlei ZhuShu Wang
Oct 19, 2012·Environmental Science & Technology·Dorota BartusikAlexander Greer
Jul 23, 2013·The Journal of Physical Chemistry. a·Jarrett H VellaKirk S Schanze
Mar 17, 2011·Langmuir : the ACS Journal of Surfaces and Colloids·Yanli TangDavid G Whitten
Mar 17, 2011·Langmuir : the ACS Journal of Surfaces and Colloids·Yanli TangDavid G Whitten
Jul 12, 2011·Langmuir : the ACS Journal of Surfaces and Colloids·Eunkyung JiDavid G Whitten
Jul 12, 2011·Langmuir : the ACS Journal of Surfaces and Colloids·Ying WangDavid G Whitten
Nov 8, 2011·Langmuir : the ACS Journal of Surfaces and Colloids·Hui ChongShu Wang
Dec 18, 2012·Langmuir : the ACS Journal of Surfaces and Colloids·Ying WangDavid G Whitten
Jul 8, 2009·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Thomas S CorbittDavid G Whitten
Jun 15, 2011·ACS Applied Materials & Interfaces·Ying WangDavid G Whitten
Jul 1, 2011·ACS Applied Materials & Interfaces·Thomas S CorbittDavid G Whitten
Jul 16, 2011·ACS Applied Materials & Interfaces·Eunkyung JiDavid G Whitten
Jul 18, 2012·Langmuir : the ACS Journal of Surfaces and Colloids·Dimitri DascierDavid G Whitten
Sep 12, 2012·Nanoscale·Guangxue FengBin Liu
Oct 23, 2015·ACS Applied Materials & Interfaces·Shouying LiChangfeng Wu
Nov 26, 2015·ACS Applied Materials & Interfaces·Harry C PappasDavid J Keller
Jan 8, 2016·Biointerphases·Linnea K IstaGabriel P López
Mar 20, 2015·ACS Applied Materials & Interfaces·Engui ZhaoBen Zhong Tang
Aug 6, 2015·Chemical Reviews·Kenneth K Ng, Gang Zheng
Aug 27, 2015·Angewandte Chemie·Haotian BaiShu Wang
Jul 15, 2009·Chemistry, an Asian Journal·Lingling An, Shu Wang
Jan 10, 2012·Small·Chengfen XingShu Wang
Mar 8, 2013·Macromolecular Rapid Communications·Hui ChongShu Wang
May 14, 2011·Macromolecular Rapid Communications·Fude FengShu Wang
May 25, 2013·Advanced Healthcare Materials·Libing LiuShu Wang
Oct 2, 2015·Chemical Communications : Chem Comm·Xinjun XuLidong Li
Apr 8, 2015·Advanced Materials·Hengjing YanGuillermo C Bazan
Nov 20, 2014·Advanced Healthcare Materials·Anjali JainWahid Khan
Jul 4, 2012·Biochimica Et Biophysica Acta·Antonio CardoneGianluca M Farinola

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