Light-induced changes in spike synchronization between coupled ON direction selective ganglion cells in the mammalian retina.

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
Jessica M AckertS A Bloomfield

Abstract

Although electrical coupling via gap junctions is prevalent among ganglion cells in the vertebrate retina, there have been few direct studies of their influence on the light-evoked signaling of these cells. Here, we describe the pattern and function of coupling between the ON direction selective (DS) ganglion cells, a unique subtype whose signals are transmitted to the accessory optic system (AOS) where they initiate the optokinetic response. ON DS cells are coupled indirectly via gap junctions made with a subtype of polyaxonal amacrine cell. This coupling underlies synchronization of the spontaneous and light-evoked spike activity of neighboring ON DS cells. However, we find that ON DS cell pairs show robust synchrony for all directions of stimulus movement, except for the null direction. Null stimulus movement evokes a GABAergic inhibition that temporally shifts firing of ON DS cell neighbors, resulting in a desynchronization of spike activity. Thus, detection of null stimulus movement appears key to the direction selectivity of ON DS cells, evoking both an attenuation of spike frequency and a desynchronization of neighbors. We posit that active desynchronization reduces summation of synaptic potentials at target AOS cells an...Continue Reading

Citations

Aug 3, 2010·Analytical and Bioanalytical Chemistry·Ian L JonesAndreas Hierlemann
Sep 22, 2011·Biological cybernetics·Mahmood AmiriFariba Bahrami
Aug 20, 2010·Journal of Computational Neuroscience·Aurel Vasile MartiniucAlois Knoll
Aug 10, 2007·Visual Neuroscience·Christianne E StrangKent T Keyser
Aug 23, 2007·Visual Neuroscience·Feng PanStephen C Massey
Aug 23, 2007·Visual Neuroscience·Stephen L MillsDavid W Marshak
Dec 21, 2007·Visual Neuroscience·Susmita ChatterjeeNorberto M Grzywacz
Jun 6, 2009·Nature Reviews. Neuroscience·Stewart A Bloomfield, Béla Völgyi
Apr 30, 2013·Journal of Integrative Neuroscience·Igor I Pushchin
Mar 6, 2007·Annual Review of Neuroscience·G D Field, E J Chichilnisky
Aug 25, 2012·Computational Intelligence and Neuroscience·Aurel Vasile Martiniuc, Alois Knoll
Sep 13, 2007·PloS One·Ernest Greene
Apr 17, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jonathon ShlensE J Chichilnisky
Aug 12, 2006·The Journal of Physiology·Wenzhi SunShigang He
Sep 18, 2013·The Journal of Physiology·D A ProttiS G Solomon
Aug 5, 2009·The Journal of Physiology·Jessica M AckertStewart A Bloomfield
Apr 5, 2014·The European Journal of Neuroscience·Martin KrauseKlaus-Peter Hoffmann
Aug 30, 2011·Trends in Neurosciences·Wei Wei, Marla B Feller
Jun 7, 2011·Current Opinion in Neurobiology·Rava Azeredo da Silveira, Botond Roska
Aug 4, 2010·Neuroscience Letters·Refik Kanjhan, Benjamin Sivyer
Oct 4, 2008·Current Opinion in Neurobiology·Jonathon ShlensEj Chichilnisky
Dec 25, 2008·The Journal of Comparative Neurology·Hideo Hoshi, Stephen L Mills
May 28, 2011·The Journal of Comparative Neurology·Hideo HoshiStephen L Mills
Jan 15, 2013·Progress in Retinal and Eye Research·Béla VölgyiRóbert Gábriel
Feb 7, 2015·Journal of Comparative Physiology. A, Neuroethology, Sensory, Neural, and Behavioral Physiology·E Popova
Apr 2, 2014·Frontiers in Neural Circuits·Jean-Philippe ThiviergeAndré Longtin
Aug 4, 2016·Frontiers in Computational Neuroscience·Ru-Jia YanPei-Ji Liang
Apr 18, 2017·Proceedings of the Japan Academy. Series B, Physical and Biological Sciences·Akihiro Matsumoto, Masao Tachibana
Feb 17, 2018·Scientific Reports·Claudio ElguetaAdrian G Palacios
Sep 14, 2007·The Journal of Comparative Neurology·Luis Pérez De Sevilla MüllerReto Weiler
Feb 9, 2012·Nature Reviews. Neuroscience·David I VaneyW Rowland Taylor
Aug 11, 2018·Annual Review of Vision Science·Wei Wei
Nov 30, 2018·Frontiers in Neural Circuits·Robert E MarcBryan William Jones
Dec 13, 2017·Nature Communications·Amurta Nath, Gregory W Schwartz
Jun 12, 2018·Annual Review of Vision Science·John O'Brien, Stewart A Bloomfield

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.