PMID: 9175144Apr 1, 1997Paper

Light-microscopic study of insulin like growth factor II (IGF-II) and insulin like growth factor I receptor (IGF-I-R) in myopathy

Neurological Research
D Heuss

Abstract

The insulin like growth factors (IGFs) are mitogenic peptides that can stimulate cell division and differentiation. In experimental studies it has been shown that there is local-production of IGFs and their mRNA in regenerating muscle. The effect of IGF-I and -II is mediated by a cell surface, membrane bound receptor (IGF-I-R). In addition, IGF-II has its own distinct type 2 receptor. But the role of IGF-II binding to the type 2 receptor is unclear, and it is now widely believed that the growth-promoting activities of IGF-II are also mediated via the IGF-I-R. So far, there is some knowledge about the regulation and effects of IGFs in muscle regeneration in vitro and in animal models in vivo. However, cell lines and in vitro experiments with myogenic precursors differ in some respects from human regenerating muscle in vivo. Thus, we performed our immunohistochemical study to investigate the potential role of IGF-II and IGF-I-R in regenerating human skeletal muscle in situ. To investigate the state of regeneration, neural cell adhesion molecule (N-CAM) and cytoskeletal protein vimentin serial sections were also performed. Light-microscopic evaluation showed that muscle fiber regeneration in inflammatory and dystrophic myopathy co...Continue Reading

Related Concepts

Related Feeds

Cell Adhesion Molecules in the Brain

Cell adhesion molecules found on cell surface help cells bind with other cells or the extracellular matrix to maintain structure and function. Here is the latest research on their role in the brain.