Light pulses do not induce c-fos or per1 in the SCN of hamsters that fail to reentrain to the photocycle

Journal of Biological Rhythms
Monique T BarakatNorman F Ruby

Abstract

Circadian activity rhythms of most Siberian hamsters (Phodopus sungorus sungorus) fail to reentrain to a 5-h phase shift of the light-dark (LD) cycle. Instead, their rhythms free-run at periods close to 25 h despite the continued presence of the LD cycle. This lack of behavioral reentrainment necessarily means that molecular oscillators in the master circadian pacemaker, the SCN, were unable to reentrain as well. The authors tested the hypothesis that a phase shift of the LD cycle rendered the SCN incapable of responding to photic input. Animals were exposed to a 5-h phase delay of the photocycle, and activity rhythms were monitored until a lack of reentrainment was confirmed. Hamsters were then housed in constant darkness for 24 h and administered a 30-min light pulse 2 circadian hours after activity onset. Brains were then removed, and tissue sections containing the SCN were processed for in situ hybridization. Sections were probed with Siberian hamster c-fos and per1 mRNA probes because light rapidly induces these 2 genes in the SCN during subjective night but not at other circadian phases. Light pulses induced robust expression of both genes in all animals that reentrained to the LD cycle, but no expression was observed in ...Continue Reading

References

Jan 1, 1975·Annual Review of Psychology·B Rusak, I Zucker
Oct 1, 1992·Brain Research. Molecular Brain Research·E L Sutin, T S Kilduff
Sep 1, 1986·Biology of Reproduction·J J Milette, F W Turek
May 1, 1995·The European Journal of Neuroscience·G E DuffieldF J Ebling
Dec 1, 1996·Brain Research. Molecular Brain Research·M I MasanaM L Dubocovich
Jul 12, 2002·Cell and Tissue Research·Jens Hannibal
Aug 29, 2002·Nature·Steven M Reppert, David R Weaver
Dec 14, 2002·Science·Norman F RubyBruce F O'Hara
Dec 14, 2002·Science·Satchidananda PandaSteve A Kay
Apr 16, 2003·Journal of Biological Rhythms·Kiho Bae, David R Weaver
Jun 28, 2003·Journal of Biological Rhythms·Mark D RollagIgnacio Provencio

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Citations

Nov 5, 2005·Brain Research. Brain Research Reviews·Ralph E Mistlberger
Dec 13, 2005·Brain Research Reviews·L P Morin, C N Allen
Dec 3, 2014·Frontiers in Neuroendocrinology·Claudia P CoomansJohanna H Meijer
Aug 3, 2012·Journal of Biological Rhythms·Brian J PrendergastIrving Zucker
Aug 1, 2006·Progress in Brain Research·Elizabeth S MaywoodMichael H Hastings
Jul 9, 2005·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Monique T BarakatNorman F Ruby
Apr 23, 2013·Journal of Biological Rhythms·Lawrence P Morin
Apr 27, 2021·Frontiers in Neuroscience·Norman F Ruby

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