PMID: 2116012Aug 1, 1990Paper

Light regulates expression of a Fos-related protein in rat suprachiasmatic nuclei

Proceedings of the National Academy of Sciences of the United States of America
N AroninW J Schwartz

Abstract

Mammalian circadian rhythmicity is endogenously generated by a pacemaker in the suprachiasmatic nuclei and precisely entrained to the 24-hr day/night cycle by periodic environmental light cues. We show that light alters the immunoreactive levels of a transcriptional regulatory protein, Fos, in the suprachiasmatic nuclei of albino rats. Photic regulation of Fos immunoreactivity does not occur in other retino-recipient brain areas except for the intergeniculate leaflet, which appears to be involved in mediating some of the complex effects of light on expressed circadian rhythms. Our results point to a promising new functional marker for the cellular effects of light and suggest that the expression of Fos or a related nuclear protein may be part of the mechanism for photic entrainment of the circadian clock to environmental light/dark cycles.

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Citations

May 1, 1996·Behavior Genetics·J M KornhauserJ S Takahashi
Jan 1, 1993·Molecular Neurobiology·T L Krukoff
Aug 6, 1993·Brain Research·T E ScammellS M Sagar
Jan 1, 1994·Neuroscience and Biobehavioral Reviews·O C Ikonomov, A G Stoynev
Jan 1, 1994·Brain Research. Brain Research Reviews·L P Morin
Oct 5, 1995·Journal of the Autonomic Nervous System·J C GrahamA F Sved
Jan 14, 1995·Brain Research. Developmental Brain Research·D A CleggT S Kilduff
Oct 1, 1995·Neuroscience Research·N Ishida
Oct 1, 1992·Brain Research. Molecular Brain Research·E L Sutin, T S Kilduff
Feb 1, 1992·Brain Research. Molecular Brain Research·D A Carter, D Murphy
Sep 1, 1992·Brain Research. Molecular Brain Research·J E JoyC R Merril
Nov 1, 1992·Brain Research. Molecular Brain Research·T S KilduffH C Heller
Jan 1, 1993·Brain Research. Molecular Brain Research·J KoistinahoS M Sagar
Jul 1, 1993·Brain Research. Molecular Brain Research·I Nir, N Agarwal
Dec 1, 1994·Brain Research. Molecular Brain Research·R V PetersW J Schwartz
Oct 1, 1994·Brain Research. Molecular Brain Research·N IshidaY Mitsui
May 1, 1996·Brain Research. Molecular Brain Research·P J ShiromaniR W McCarley
Feb 1, 1994·Neurochemistry International·P J MorganR Helliwell
Sep 1, 1993·Neurobiology of Aging·E L SutinT S Kilduff
May 11, 1992·Neuroscience Letters·L Giovannelli, F E Bloom
Nov 24, 1995·Neuroscience Letters·A SumováH Illnerová
Jun 9, 1995·Neuroscience Letters·D A Golombek, M R Ralph

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