Light-Switchable Ion Channels and Receptors for Optogenetic Interrogation of Neuronal Signaling

Bioconjugate Chemistry
Wan-Chen Lin, Richard H Kramer

Abstract

Optogenetics is an emerging technique that enables precise and specific control of biological activities in defined space and time. This technique employs naturally occurring or engineered light-responsive proteins to manipulate the physiological processes of the target cells. To better elucidate the molecular bases of neural functions, substantial efforts have been made to confer light sensitivity onto ion channels and neurotransmitter receptors that mediate signaling events within and between neurons. The chemical strategies for engineering light-switchable channels/receptors and the neuronal implementation of these tools are discussed.

References

Nov 24, 2004·Nature Neuroscience·Matthew BanghartRichard H Kramer
Jan 13, 2006·Nature Chemical Biology·Matthew VolgrafDirk Trauner
May 25, 2007·Neuron·Stephanie SzobotaEhud Y Isacoff
Jun 21, 2007·Proceedings of the National Academy of Sciences of the United States of America·Pau GorostizaEhud Y Isacoff
Oct 30, 2010·Current Opinion in Biotechnology·Marlon J Hinner, Kai Johnsson
Apr 13, 2011·Chemical Society Reviews·Andrew A Beharry, G Andrew Woolley
Apr 29, 2011·Journal of Neurophysiology·Doris L FortinRichard H Kramer
May 26, 2011·Molecular Therapy : the Journal of the American Society of Gene Therapy·Natalia CaporaleJohn G Flannery
Aug 9, 2011·Annual Review of Cell and Developmental Biology·Gero Miesenböck
Nov 16, 2011·Journal of the American Chemical Society·Andrew A BeharryG Andrew Woolley
Dec 27, 2011·Cell·Feng ZhangKarl Deisseroth
Mar 5, 2013·Nature Neuroscience·Joshua LevitzEhud Y Isacoff
Mar 22, 2013·Chemical Reviews·Candice E Paulsen, Kate S Carroll
Jun 12, 2013·Journal of the American Chemical Society·Subhas SamantaG Andrew Woolley
Jun 27, 2013·Nature Neuroscience·Adam M PackerMichael Häusser
Jun 27, 2013·Nature Neuroscience·Richard H KramerHillel Adesnik
Nov 1, 2013·Journal of the American Chemical Society·Michael A KienzlerEhud Y Isacoff
Dec 4, 2013·Proceedings of the National Academy of Sciences of the United States of America·Damien LemoineThomas Grutter
Dec 25, 2013·Proceedings of the National Academy of Sciences of the United States of America·Liam E BrowneR Alan North
May 14, 2014·ACS Chemical Biology·Wan-Chen LinRichard H Kramer
May 27, 2014·Journal of the American Chemical Society·Mercè Izquierdo-SerraPau Gorostiza
Aug 3, 2014·Cold Spring Harbor Protocols·Antoine R AdamantidisKarl Deisseroth
Oct 30, 2014·Chemistry : a European Journal·Christopher KnieDavid Bléger
Dec 10, 2014·Proceedings of the National Academy of Sciences of the United States of America·Benjamin M GaubEhud Y Isacoff
Feb 6, 2015·Proceedings of the National Academy of Sciences of the United States of America·Elizabeth C CarrollEhud Y Isacoff
Mar 7, 2015·Chemical Communications : Chem Comm·J BroichhagenD J Hodson
Sep 29, 2015·Accounts of Chemical Research·Mingxin DongG Andrew Woolley
Feb 13, 2016·Frontiers in Molecular Neuroscience·Joshua LevitzEhud Y Isacoff
Mar 2, 2016·ELife·Shai BerlinEhud Y Isacoff
May 11, 2016·ACS Central Science·Johannes BroichhagenDirk Trauner
Nov 1, 2016·ACS Infectious Diseases·Claire E WestonMatthew J Fuchter
Dec 24, 2016·Journal of the American Chemical Society·Joaquín CalboMatthew J Fuchter
Apr 12, 2017·Proceedings of the National Academy of Sciences of the United States of America·Joshua LevitzEhud Y Isacoff
Jun 9, 2017·Annual Review of Chemical and Biomolecular Engineering·Nicole A RepinaRavi S Kane
Jul 28, 2017·Journal of the American Chemical Society·Joshua E Zweig, Timothy R Newhouse
Sep 26, 2017·Journal of the American Chemical Society·Christian PetermayerHenry Dube
Nov 23, 2017·Journal of the American Chemical Society·Prashant C DonthamsettiDirk Trauner
Dec 2, 2017·Nature Communications·Michael H BerryEhud Y Isacoff

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Citations

May 31, 2018·Chemical Communications : Chem Comm·V DhamodharanYohei Yokobayashi
Feb 18, 2020·Chemistry : a European Journal·Jie XuKiyohiko Kawai
Jun 13, 2020·Chembiochem : a European Journal of Chemical Biology·Ivana Nikić-Spiegel

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