Light to Moderate Alcohol Consumption Is Associated With Lower Risk of Aortic Valve Sclerosis: The Study of Health in Pomerania (SHIP)

Arteriosclerosis, Thrombosis, and Vascular Biology
Marcello Ricardo Paulista MarkusSebastian E Baumeister

Abstract

In developed countries, sclerotic and calcific degeneration of the aortic valve is a common disorder showing pathophysiologic similarities with atherothrombotic coronary disease. Light to moderate alcohol consumption has been associated with a lower risk for atherothrombotic coronary disease and mortality. Whether alcohol consumption affects the development of aortic valve sclerosis (AVS) is not well known. In the present study, we aim to analyze the cross-sectional association between average daily alcohol consumption and AVS in the general population. We analyzed cross-sectional data from 2022 men and women, aged 45 to 81 years, from the population-based Study of Health in Pomerania. We used a computer-assisted interview that included beverage-specific questions about quantity and frequency of alcohol over the last 30 days to calculate the average quantity of alcohol consumption (in grams of ethanol per day). AVS was ascertained by echocardiography. The prevalence of AVS was 32.3%. Average daily alcohol intake displayed a J-type relation with AVS (fully adjusted P value: 0.005). Compared with individuals with an average consumption of 10 g of alcohol per day, multivariable-adjusted odds ratios were 1.60 (95% confidence interv...Continue Reading

References

Nov 15, 1990·The American Journal of Cardiology·A L KlatskyG D Friedman
Aug 4, 1988·The New England Journal of Medicine·M J StampferC H Hennekens
Apr 1, 1993·Journal of the American College of Cardiology·M LindroosR Tilvis
Mar 1, 1997·Journal of the American College of Cardiology·B F StewartC M Otto
Jan 19, 1999·JAMA : the Journal of the American Medical Association·R L SaccoM C Paik
Jul 10, 1999·American Journal of Epidemiology·G I FeunekesF J Kok
Jul 15, 1999·The New England Journal of Medicine·C M OttoD S Siscovick
Jun 19, 2002·Circulation·Augusto Di CastelnuovoGiovanni De Gaetano
Feb 13, 2003·JAMA : the Journal of the American Medical Association·Kristi ReynoldsBrian L Lewis
Sep 23, 2003·QJM : Monthly Journal of the Association of Physicians·S Kamath, G Y H Lip
Dec 24, 2003·The Journal of Nutritional Biochemistry·Shela GorinsteinSimon Trakhtenberg
Jan 23, 2004·Journal of the American College of Cardiology·Harish R ChandraWilliam W O'Neill
Dec 13, 2005·American Heart Journal·Henry VölzkeThomas Kocher
Jun 7, 2006·Epidemiology·Miguel A Hernán, James M Robins
Sep 19, 2006·Lancet·Vuyisile T NkomoMaurice Enriquez-Sarano
Dec 13, 2006·Archives of Internal Medicine·Augusto Di CastelnuovoGiovanni de Gaetano
Apr 26, 2007·Nature Clinical Practice. Cardiovascular Medicine·Nalini M RajamannanShahbudin H Rahimtoola
Apr 17, 2008·British Journal of Pharmacology·D BusseuilJ-C Tardif
May 29, 2009·Journal of the American Geriatrics Society·Sei J LeeKenneth E Covinsky
Mar 27, 2010·Journal of the American College of Cardiology·Kenneth J MukamalRosalind A Breslow
Mar 27, 2010·Journal of the American College of Cardiology·Simona CostanzoGiovanni de Gaetano
Jun 1, 2010·Journal of the American College of Cardiology·George ThanassoulisSekar Kathiresan
Feb 10, 2011·Nature Reviews. Cardiology·Mohamad NavabAlan M Fogelman
Jan 27, 2012·Journal of Proteome Research·Tatiana Martín-RojasMaria G Barderas
May 21, 2013·Arteriosclerosis, Thrombosis, and Vascular Biology·Marcello Ricardo Paulista MarkusWolfgang Lieb
Jul 9, 2013·Circulation Research·Donald D HeistadLinda L Demer
Jul 9, 2013·Circulation Research·Brian R LindmanCatherine M Otto
Sep 6, 2013·The New England Journal of Medicine·Majid Ezzati, Elio Riboli
Jun 12, 2014·European Heart Journal·Henning JansenHeribert Schunkert
Jul 12, 2014·BMJ : British Medical Journal·Michael V HolmesUNKNOWN InterAct Consortium

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Citations

May 11, 2015·Metabolism: Clinical and Experimental·Alessandro MantovaniGiovanni Targher
May 12, 2017·Journal of Internal Medicine·S C LarssonM Bäck
Jul 23, 2016·International Journal of Environmental Research and Public Health·Zhao LiMaria Roselle Abraham
Nov 7, 2019·Cardiovascular Diabetology·Marcello Ricardo Paulista MarkusMarcus Dörr
Sep 26, 2019·Frontiers in Microbiology·Breno Pereira de PaulaMaria Alice Zarur Coelho
Oct 24, 2017·European Journal of Preventive Cardiology·Sebastian E BaumeisterMichael F Leitzmann
Feb 26, 2021·Therapeutic Advances in Cardiovascular Disease·Hataw Al-TaeshSeyithan Taysi
May 28, 2021·Frontiers in Cardiovascular Medicine·Petra BüttnerFlorian Schlotter
Nov 23, 2017·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·M R P MarkusH J Grabe

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