Light-Triggered Biomimetic Nanoerythrocyte for Tumor-Targeted Lung Metastatic Combination Therapy of Malignant Melanoma

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Wen LiuWei Xue

Abstract

Red blood cell (RBC) membrane-cloaked nanoparticles, reserving the intact cell membrane structure and membrane protein, can gain excellent cell-specific functions such as long blood circulation and immune escape, providing a promising therapy nanoplatform for drug delivery. Herein, a novel RBC membrane biomimetic combination therapeutic system with tumor targeting ability is constructed by embedding bovine serum albumin (BSA) encapsulated with 1,2-diaminocyclohexane-platinum (II) (DACHPt) and indocyanine green (ICG) in the targeting peptide-modified erythrocyte membrane (R-RBC@BPtI) for enhancing tumor internalization and synergetic chemophototherapy. R-RBC@BPtI displays excellent stability and high encapsulation efficiency with multiple cores enveloped in the membrane. Benefited from the stealth functionality and targeting modification of erythrocyte membranes, R-RBC@BPtI can significantly promote tumor targeting and cellular uptake. Under the near-infrared laser stimuli, R-RBC@BPtI presents remarkable instability by singlet oxygen and heat-mediated cleavage so as to trigger effective drug release, thereby achieving deep penetration and accumulation of DACHPt and ROS in the tumor site. Consequently, R-RBC@BPtI with tumor-speci...Continue Reading

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Citations

Feb 14, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Zhongxiong FanZhenqing Hou
Jul 23, 2020·Journal of Cellular Physiology·Emel RothzergJiake Xu
Nov 14, 2018·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Wen LiuWei Xue
Feb 16, 2021·Advanced Healthcare Materials·Faisal RazaQiu Mingfeng
Dec 29, 2020·Drug Design, Development and Therapy·Meilin ZhangBaoan Chen
Mar 7, 2021·International Journal of Molecular Sciences·Mingming SongWenxiang Zhang
May 27, 2020·Biochemistry·Xiangzhao AiLiangfang Zhang
May 6, 2021·Nanoscale·Akmal M AsrorovYongzhuo Huang
Jun 9, 2021·Signal Transduction and Targeted Therapy·Li ChenZhiyao He
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Jun 18, 2021·Nano-micro Letters·Shruti Rawal, Mayur Patel
Oct 26, 2021·Advanced Science·Yixiao YangGaoxing Luo
Nov 6, 2021·Advanced Materials·Yuemin WangJianshu Li

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