Light-triggered release of drug conjugates for an efficient combination of chemotherapy and photodynamic therapy

Biomaterials Science
Lin LiuJianjun Cheng

Abstract

Herein, we present a series of light-triggered porphyrin-based polymeric drug conjugates PSDTD-m for combined chemo-photodynamic therapy of cancer. The controlled release of a drug through a ROS-cleavable linker combined with photodynamic therapy showed enhanced anticancer efficacy, proving the effectiveness of this light triggered smart nanocarrier platform for enhancing the therapy efficacy.

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Citations

Dec 21, 2018·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Rongrong NieHui Wang
Nov 21, 2019·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Faisal RazaLiang Ge
Dec 29, 2018·Journal of Controlled Release : Official Journal of the Controlled Release Society·Camila G DarivaArménio C Serra
Dec 31, 2020·International Journal of Molecular Sciences·Fasih Bintang IlhamiChih-Chia Cheng
Feb 6, 2020·Bioorganic Chemistry·Kinga PioreckaWlodzimierz A Stanczyk
Apr 21, 2018·Biomacromolecules·Santhosh Kalash RajendrakumarIn-Kyu Park

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Methods Mentioned

BETA
flow cytometry

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