Ligliptin for treatment of type 2 diabetes mellitus with early renal injury: Efficacy and impact on endogenous hydrogen sulfide and endothelial function

World Journal of Clinical Cases
Jian ZhangWei-Kai Hou

Abstract

Diabetes is a clinically common chronic disease, and its incidence has been increasing in recent years. Diabetes is believed to accelerate the process of atherosclerosis in patients, and abnormal endothelial function is an important factor leading to diabetic kidney damage. To investigate the efficacy of ligliptin in the treatment of type 2 diabetes mellitus (T2DM) with early renal injury and its effect on serum endogenous hydrogen sulfide (H2S), endothelial cell particles, and endothelial function. From January 2018 to April 2019, 110 patients with T2DM and early kidney injury treated at our hospital were divided into an observation group (receiving ligliptin treatment, n = 54) and a control group (receiving gliquidone therapy, n = 56). Blood glucose and renal function before and after treatment were compared between the two groups. The differences in fasting blood glucose, 2 h blood glucose, and glycated hemoglobin were not statistically significant between the two groups after treatment. The urinary albumin excretion rate after treatment in the ligliptin group was 70.32 ± 11.21 µg/min, which was significantly lower than that of the gliquidone group (P = 0.000). Serum endogenous H2S and endothelial cell microparticles of the ...Continue Reading

References

Apr 5, 2007·Current Medical Research and Opinion·Richard E Pratley, Afshin Salsali
Jan 17, 2014·Journal of Nephrology·Daniel PatschanGerhard Anton Müller
Aug 31, 2017·Kidney & Blood Pressure Research·Ntethelelo SibiyaMusa Mabandla
Oct 11, 2017·Biochimica Et Biophysica Acta. Molecular Basis of Disease·Aline L CortesLucienne S Lara
Dec 1, 2017·American Journal of Physiology. Renal Physiology·Masahiro EriguchiJorge F Giani

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Methods Mentioned

BETA
glycosylation
enzyme-linked immunosorbent assay

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