Lignan compounds and 4,4'-dihydroxybiphenyl protect C2C12 cells against damage from oxidative stress

Biochemical and Biophysical Research Communications
Ayumu YoshikawaKei Maruyama

Abstract

Lignan compounds are known to have various biological activities, especially antioxidative effects. We investigated whether lignan compounds show antioxidative activity in myoblast C2C12 cells. Among 14 lignan compounds investigated, two lignans containing two phenolic functional groups, namely Gomisin J and GR-12, prevented hydrogen peroxide (H(2)O(2))-induced cell death. A simple compound, 4,4'-dihydroxybiphenyl, which was found to be a common component of Gomisin J and GR-12, also largely prevented H(2)O(2)-induced cell death and almost completely prevented H(2)O(2)-induced increases in p38 MAPK phosphorylation. Our present results provide a useful in vitro system for clarifying the molecular mechanisms of lignan-mediated antioxidative effects and evaluating lead molecules toward the development of therapeutic drugs.

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Citations

Aug 8, 2007·Archives of Pharmacal Research·Tran Manh HungKiHwan Bae
Apr 9, 2010·Apoptosis : an International Journal on Programmed Cell Death·Solaleh Khoramian TusiFariba Khodagholi
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Jan 18, 2011·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Seung-Hwan KwonChoon-Gon Jang
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Mar 3, 2007·The Journal of Pharmacy and Pharmacology·Chang Hwa JungHo Moon Seog

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