Lignan Glycosides from Urena lobata

Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry
Yuan LuoShepo Shi

Abstract

Four new lignan glycosides; urenalignosides A-D (1-4), along with 12 known ones (5-16) were isolated from Urena lobata. Their structures were determined on the basis of extensive spectroscopic and spectrometric data (1D and 2D NMR; IR; CD; and HRESIMS). Compounds 2-4; 6; 7; 10; and 11 showed inhibition of nitric oxide production in lipopolysaccharide-induced RAW 264.7 macrophage cells with IC50 values in the range of 25.5-98.4 μM (positive control; quercetin; IC50 = 7.2 ± 0.2 μM).

References

Jul 31, 1998·Journal of Ethnopharmacology·B de las HerasX Chiriboga
Aug 23, 2001·Chemical & Pharmaceutical Bulletin·Z H JiangI Kouno
Dec 4, 2001·Fitoterapia·U K MazumderS Bhattacharya
Apr 9, 2002·Phytochemistry·Luis GóngoraJosé Luis Ríos
Nov 18, 2005·Phytochemistry·Aranya JutiviboonsukHarry H S Fong
May 16, 2006·Fitoterapia·Carlo F MorelliSultana Rajia
Jun 10, 2006·Phytochemistry·Zhen-Dan HeHong-Jie Zhang
Aug 11, 2006·Journal of Ethnobiology and Ethnomedicine·Albert L Sajem, Kuldip Gosai
Mar 11, 2008·Journal of Natural Products·Maoluo GanNaihong Chen
Feb 3, 2009·Journal of Natural Medicines·Koichi MachidaMasao Kikuchi
Sep 26, 2009·Natural Product Reports·Jian-Yu PanKun Zou
May 1, 2010·Environmental Toxicology and Pharmacology·C A PiemeM Costache
Jan 10, 2012·Journal of Agricultural and Food Chemistry·Ya-nan YangPei-cheng Zhang
Mar 5, 2015·International Journal of Molecular Sciences·Xiao-Ling GaoZheng-Jun Xu
Feb 16, 2018·Fitoterapia·Cong SuShe-Po Shi

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Methods Mentioned

BETA
NMR
column chromatography

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