Lignans from Tujia Ethnomedicine Heilaohu: Chemical Characterization and Evaluation of Their Cytotoxicity and Antioxidant Activities

Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry
Yongbei LiuWei Wang

Abstract

Heilaohu, the roots of Kadsura coccinea, has a long history of use in Tujia ethnomedicine for the treatment of rheumatoid arthritis and gastroenteric disorders, and a lot of work has been done in order to know the material basis of its pharmacological activities. The chemical investigation led to the isolation and characterization of three new (1⁻3) and twenty known (4⁻23) lignans. Three new heilaohulignans A-C (1⁻3) and seventeen known (4⁻20) lignans possessed dibenzocyclooctadiene skeletons. Similarly, one was a diarylbutane (21) and two were spirobenzofuranoid dibenzocyclooctadiene (22⁻23) lignans. Among the known compounds, 4⁻5, 7, 13⁻15 and 17⁻22 were isolated from this species for the first time. The structures were established, using IR, UV, MS and NMR data. The absolute configurations of the new compounds were determined by circular dichroism (CD) spectra. The isolated lignans were further evaluated for their cytotoxicity and antioxidant activities. Compound 3 demonstrated strong cytotoxic activity with an IC50 value of 9.92 µM, compounds 9 and 13 revealed weak cytotoxicity with IC50 values of 21.72 µM and 18.72 µM, respectively in the HepG-2 human liver cancer cell line. Compound 3 also showed weak cytotoxicity against...Continue Reading

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Citations

Oct 11, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Sheng Zhuo HuangHao Fu Dai
Jun 12, 2020·Natural Product Research·Nuzhat ShehlaWei Wang
Apr 14, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·David Barker
Jul 9, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Hee-Sung ChaeYoung-Won Chin
Mar 9, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Carmen Rodríguez-GarcíaJosé J Gaforio
May 1, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Liang CaoWei Wang
Feb 11, 2020·Food Research International·Ileana GonzálezArmando Rojas

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Methods Mentioned

BETA
NMR
column chromatography
Assay
PMA

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