Likelihood-based experimental design for estimation of ED50

Biometrics
S Minkin, K Kundhal

Abstract

In selecting the best dosage choice for the estimation of ED50, it is natural to try to minimize the length of the confidence intervals. In this presentation, the dose allocation that minimizes the length of the likelihood-based confidence intervals is presented and compared with alternative allocations that have been proposed based on the length of different types of confidence intervals, such as those based on the asymptotic variance or on Fieller's Theorem. Effective strategies to deal with the parameter dependence of these allocations are explored. A series of experiments to evaluate the effect of small doses per fraction on the radiation tolerance of the rat cervical spinal cord provide the motivation and an illustration for the proposed procedures.

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Citations

May 3, 2008·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Chin C ChuJhi J Wang
May 4, 2010·Acta Anaesthesiologica Taiwanica : Official Journal of the Taiwan Society of Anesthesiologists·Yu-Wen ChenCheng-Hsing Kao
Dec 29, 2000·Biometrics·J King, W K Wong
Mar 23, 2007·Anesthesia and Analgesia·Jann-Inn TzengJhi-Joung Wang
Aug 25, 2015·Fundamental & Clinical Pharmacology·Yu-Wen ChenJhi-Joung Wang
Nov 3, 2011·European Journal of Pharmacology·Ching-Hsia HungJhi-Joung Wang
Mar 8, 2016·Neuroscience Letters·Jann-Inn TzengChing-Hsia Hung
Jul 3, 2007·European Journal of Pharmacology·Yu-Wen ChenCheng-Hsing Kao
Sep 6, 2013·Fundamental & Clinical Pharmacology·Yu-Wen ChenChing-Hsia Hung
Sep 17, 2015·European Journal of Pharmacology·Ching-Hsia HungJhi-Joung Wang
Jun 7, 2012·Neuroscience Letters·Yu-Wen ChenJhi-Joung Wang
Dec 3, 2014·European Journal of Pharmacology·Yuk-Man LeungJhi-Joung Wang
Sep 11, 2014·European Journal of Pharmacology·Yu-Wen ChenJhi-Joung Wang
Jul 23, 2013·European Journal of Pharmacology·Yuk-Man LeungJhi-Joung Wang
Jul 26, 2011·Neuroscience Letters·Ching-Hsia HungJhi-Joung Wang
Feb 24, 2010·Neuropharmacology·Yuk-Man LeungYu-Wen Chen
Dec 8, 2009·Neuroscience Letters·Yu-Wen ChenChing-Hsia Hung
Oct 27, 2011·Neuroscience Letters·Kuo-Lun HuangMou-Yung Yeh
Feb 24, 2015·European Journal of Pharmacology·Jann-Inn TzengJhi-Joung Wang
Mar 25, 2016·Fundamental & Clinical Pharmacology·Jann-Inn TzengChing-Hsia Hung
May 31, 2018·Anesthesia and Analgesia·An-Kuo ChouChing-Hsia Hung
Jun 8, 2013·Pharmacological Reports : PR·Yuk-Man LeungJhi-Joung Wang
Feb 15, 2018·The Journal of Pharmacy and Pharmacology·An-Kuo ChouChing-Hsia Hung
May 17, 2019·Anesthesia and Analgesia·An-Kuo ChouChing-Hsia Hung
Jul 6, 2020·Neuroscience Letters·Ying-Jen ChangYu-Wen Chen
Apr 2, 2021·The Journal of Pharmacy and Pharmacology·Ying-Jen ChangChing-Hsia Hung
Jan 15, 2019·European Journal of Pharmacology·An-Kuo ChouChing-Hsia Hung

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