Likelihood of Diagnosing Neuroblastoma in Isolated Horner Syndrome

Journal of Neuro-ophthalmology : the Official Journal of the North American Neuro-Ophthalmology Society
Avi Ben ShabatNitza Goldenberg-Cohen

Abstract

The need for an extensive evaluation for neuroblastoma in children with Horner syndrome is controversial. A retrospective study design was used. The cohort included 47 children with anisocoria who were diagnosed with Horner syndrome and 135 children with neuroblastoma evaluated at a pediatric medical center between 2007 and 2015. To detect neuroblastoma, patients with Horner syndrome underwent brain and cervical MRI, abdominal ultrasound, and/or measurement of urinary vanillylmandelic acid (VMA). The neuroblastoma group was evaluated for signs/symptoms of Horner syndrome at the time of diagnosis. Seven patients with Horner syndrome were lost to follow-up, and the findings of the remaining 40 were categorized according to the age of the patient. Horner syndrome most frequently was idiopathic (58%), and in only 1 patient did the discovery of neuroblastoma precede the appearance of Horner syndrome. In the 21 patients aged 1-18 years, Horner syndrome was acquired in 15 patients and congenital in 6. The most common etiology was trauma (62%). Imaging was performed in 14 patients and VMA testing in 13. Neuroblastoma was diagnosed in 5 patients; in none was it related to Horner syndrome. In the 135 patients with neuroblastoma, most of ...Continue Reading

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Citations

Dec 27, 2019·Ophthalmic Plastic and Reconstructive Surgery·Selma UrfaliogluMeliha Kübra Kütükcü
Oct 8, 2020·Pediatric Radiology·Hedieh Khalatbari, Gisele E Ishak
Oct 19, 2020·Archivos de la Sociedad Española de Oftalmología·M R Pérez-Torres-LobatoJ L Sánchez-Vicente
Nov 29, 2021·Journal of Neurology·Claire BellégoAki Kawasaki

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