Likelihood ratio of computed tomography characteristics for diagnosis of malignancy in adrenal incidentaloma: systematic review and meta-analysis

Journal of Diabetes and Metabolic Disorders
Fatemeh Alsadat SabetAkbar Soltani


To propose an evidence based diagnostic algorithm using mass characteristics to determine malignancy in patients with adrenal incidentaloma by CTscan. A systematic review in Medline, Scopus, relevant reference books and desk searching was performed up to January 2016 with relevant reference checking. The summery estimates of sensitivity, specificity, positive and negative likelihood ratio of different characteristics were calculated in two groups of the articles investigating the cases without previous malignancy and the articles investigating the oncologic cases. Thirty six articles were included in this study. In the first group with no history of malignancy a positive and negative LR of 3.1 and 0.13 in 4 cm threshold and positive and negative LR of 2.85 and 0 in 10HU density were found. In the second group with history of malignancy positive and negative LR of 2.3 and 0.27 in 3 cm threshold and positive and negative LR of 3.6 and 0.08 in 20HU density were resulted. The results retrieved in this study considering the limitations show that adrenal incidentaloma with a size less than 4 cm or a mass larger than 4 cm with density less than 10HU in the first group can be managed with imaging follow up. For masses larger than 4 cm ...Continue Reading


Oct 1, 1990·Endocrinologia Japonica·N YamakitaK Miura
Jul 1, 1990·Journal of Endocrinological Investigation·J M LópezF Cruz
Sep 1, 1988·Acta Radiologica·M PäivänsaloM Kallionen
Jan 1, 1985·AJR. American Journal of Roentgenology·S HussainH L Abrams
Dec 1, 1995·AJR. American Journal of Roentgenology·M M McNicholasPeter R Mueller
Aug 1, 1995·Seminars in Ultrasound, CT, and MR·Melvyn Korobkin, Isaac R Francis
Jun 1, 1995·The Surgical Clinics of North America·E D Staren, R A Prinz
Sep 1, 1994·Radiographics : a Review Publication of the Radiological Society of North America, Inc·M J LeeN Papanicolaou
May 1, 1994·Cleveland Clinic Journal of Medicine·A A SingerD M Paushter
May 1, 1994·Journal of Computer Assisted Tomography·A R van ErkelT H Falke
Jul 1, 1996·The American Journal of Medicine·D M Cook, D L Loriaux
Mar 1, 1997·Radiology·Giles W L BolandPeter R Mueller
Jan 1, 1997·Clinical Endocrinology·A A Kasperlik-ZeluskaH Snochowska
Jan 16, 1998·Endocrinology and Metabolism Clinics of North America·D M Cook
Feb 18, 1998·Current Opinion in Oncology·P C McGrathD E Kenady
Apr 16, 1998·Radiographics : a Review Publication of the Radiological Society of North America, Inc·A KawashimaS M Goldman
Jun 26, 1998·Clinical Endocrinology·P D PeppercornR H Reznek
Jul 2, 1998·AJR. American Journal of Roentgenology·Giles W L BolandPeter R Mueller
Apr 28, 1999·Journal of Surgical Oncology·N B Tütüncü, O Gedik
Jul 9, 1999·Clinical Endocrinology·F Mantero, G Arnaldi
Mar 25, 2000·Endocrinology and Metabolism Clinics of North America·F Mantero, G Arnaldi
Mar 25, 2000·Endocrinology and Metabolism Clinics of North America·D E Schteingart
Sep 27, 2001·World Journal of Surgery·L M Brunt, J F Moley
Nov 14, 2001·Reviews in Endocrine & Metabolic Disorders·D C Aron
Jan 26, 2002·European Journal of Radiology·Mark E LockhartPhilip J Kenney
Sep 14, 2002·Cancer Control : Journal of the Moffitt Cancer Center·Sergio G Moreira, Julio M Pow-Sang
Sep 25, 2002·Journal of Internal Medicine·B BülowSwedish Research Council Study Group of Endocrine Abdominal Tumours
Dec 19, 2002·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Tetsuo NishikawaMasao Omura
Dec 20, 2002·Current Opinion in Oncology·Geoffrey B Thompson, William F Young
Mar 5, 2003·Annals of Internal Medicine·Melvin M GrumbachH Samuel Wieand
Jan 22, 2004·Current Urology Reports·Ravi MunverIhor S Sawczuk
Apr 15, 2004·Endocrine Reviews·Georg MansmannStefan R Bornstein
Sep 11, 2004·Trends in Endocrinology and Metabolism : TEM·A Sahdev, R H Reznek
Nov 13, 2004·Journal of Computer Assisted Tomography·Hubert GuflerGabriele Grau
Jan 20, 2005·Surgery·Andrea FrillingChristoph Broelsch
Mar 12, 2005·Arquivos brasileiros de endocrinologia e metabologia·F Mantero, Nora Albiger
Mar 15, 2005·Best Practice & Research. Clinical Endocrinology & Metabolism·Mahmoud M Al-HawaryMelvyn Korobkin
Jun 21, 2006·Cleveland Clinic Journal of Medicine·Thottathil GopanAmir H Hamrahian
Aug 5, 2006·Urologia Internationalis·A Meyer, M Behrend
Dec 5, 2006·Current Opinion in Urology·Gertraud Heinz-PeerBruno Niederle
Aug 4, 2007·Korean Journal of Radiology : Official Journal of the Korean Radiological Society·Sung Hee ParkKi Whang Kim
Oct 9, 2007·Cancer Imaging : the Official Publication of the International Cancer Imaging Society·A Sahdev, R H Reznek
Apr 22, 2008·World Journal of Surgery·P R K BhargavSaroj Kanta Mishra
May 9, 2008·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Lucio VilarLuciana A Naves
Jun 9, 2009·Best Practice & Research. Clinical Endocrinology & Metabolism·M TerzoloAlberto Angeli
Jun 10, 2009·Nature Reviews. Urology·Milton D GrossMehdi Djekidel
Jul 25, 2009·Wiener klinische Wochenschrift·Ersin OzturkC Cinar Basekim
Aug 13, 2009·Hormones : International Journal of Endocrinology and Metabolism·Panagiotis AnagnostisDimitri P Mikhailidis
Jan 8, 2011·European Journal of Clinical Investigation·Ioannis I AndroulakisAshley B Grossman
Feb 22, 2011·Radiologic Clinics of North America·Julie H Song, William W Mayo-Smith
Apr 8, 2011·European Journal of Endocrinology·M TerzoloItalian Association of Clinical Endocrinologists
Apr 9, 2013·The Journal of Surgical Research·Bassan J AllanJohn I Lew
May 28, 2014·International Journal of Surgery·Alfonso ReginelliRoberto Grassi


Sep 13, 2018·AJR. American Journal of Roentgenology·Wendy TuNicola Schieda
Dec 4, 2019·Ultrasonography·Christoph F DietrichChristian Jenssen
May 27, 2020·Radiology·Nicole M Hindman, Alec J Megibow

Methods Mentioned

imaging techniques

Related Concepts

Malignant Neoplasms
Diagnostic Imaging
X-Ray Computed Tomography
Diagnostic Procedures on Testes
Meta Analysis (Statistical Procedure)
Adrenal Incidentaloma
Clinical Study Follow-up

Related Feeds

Cancer Imaging

Imaging techniques, including CT and MR, have become essential to tumor detection, diagnosis, and monitoring. Here is the latest research on cancer imaging.

Related Papers

Trends in Endocrinology and Metabolism : TEM
M L Adler, R J Robbins
Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association
Ana Laura PimentelJoíza Lins Camargo
The Korean Journal of Internal Medicine
Jee-Young Oh
© 2021 Meta ULC. All rights reserved