PMID: 8596265Feb 24, 1996Paper

Limb defects and chorionic villus sampling: results from an international registry, 1992-94

Lancet
U G Froster, L Jackson

Abstract

Several reports of limb defects occurring among infants exposed to chorionic villus sampling (CVS) during pregnancy resulted in concern about the safety of this procedure for prenatal diagnosis. To avoid publication bias and evaluate the true risk of limb defects in a CVS cohort, the World Health Organization initiated international registration of post-CVS limb defects in 1992. From May, 1992, to May, 1994, 77 infants or fetuses with limb defects from 138 996 pregnancies having CVS were reported to the WHO CVS Registry. These cases were analysed by standardised methods-ie, exclusion of syndromes, inherited disorders, and defects occurring in previable fetuses. The included limb deficiencies were studied by pattern analysis. Defects of the upper limbs were reported in 64.6%, of the lower limbs in 12.5%, and of both upper and lower limbs in 20.8% of cases. These figures are in agreement with the distribution of limb defects in several large population-based studies. Transverse limb defects occurred in 40.8% and longitudinal defects in 59.2%, compared with 42.7% and 57.3% in an unexposed population. The analysis of this cohort did not show any differences from the background population in the overall frequency or pattern distribu...Continue Reading

References

Jan 4, 1992·Lancet·U G Froster, P A Baird
Sep 12, 1992·Lancet·A M KulievL Jackson
Dec 1, 1992·American Journal of Medical Genetics·P MastroiacovoF Petroni
Oct 1, 1992·American Journal of Medical Genetics·J S Bamforth
Feb 1, 1992·American Journal of Medical Genetics·R SchlooW Lenz
Jul 1, 1992·Paediatric and Perinatal Epidemiology·C StollM P Roth
May 4, 1991·Lancet·Pierpaolo MastroiacovoAlan Fantel
Jan 1, 1990·Teratology·U G Froster-Iskenius, P A Baird
Feb 1, 1989·Teratology·U G Froster-Iskenius, P A Baird
Mar 12, 1983·Lancet·B Brambati, G Simoni
Sep 1, 1982·International Journal of Epidemiology·T AroL Saxén
Mar 1, 1993·Prenatal Diagnosis·A M KulievW Holzgreve
Jun 15, 1993·American Journal of Medical Genetics·U G Froster, P A Baird
Jun 15, 1993·American Journal of Medical Genetics·U G Froster, P A Baird
Jan 1, 1993·American Journal of Medical Genetics·U G Froster, P A Baird

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Citations

Oct 19, 2002·Urology·John M GattiCharlotte A Massad
May 18, 1996·Lancet·H FirthS M Huson
Feb 11, 1998·Lancet·M J Whittle
Feb 9, 2000·Clinical Genetics·J E Polifka, J M Friedman
Mar 11, 2005·Current Opinion in Obstetrics & Gynecology·Bruno Brambati, Lucia Tului
Apr 5, 2008·Current Opinion in Obstetrics & Gynecology·Mark I Evans, Stephanie Andriole
Feb 8, 2011·Current Opinion in Obstetrics & Gynecology·Antonio Farina
Dec 24, 1997·Acta Paediatrica·A GreenoughK H Nicolaides
Oct 1, 1996·Archives of Disease in Childhood·M M Lees, R M Winter
Jan 1, 1997·American Journal of Public Health·K Källén
Jan 1, 1996·Journal of Inherited Metabolic Disease·W LissensI Liebaers
Jun 21, 2012·Seminars in Perinatology·Joy VinkMary E D'Alton
Oct 22, 2011·Clinics in Dermatology·Kalpana ReddySharon A Glick
Mar 22, 2005·BJOG : an International Journal of Obstetrics and Gynaecology·Maria CederholmOve Axelsson
Sep 10, 2003·Birth Defects Research. Part A, Clinical and Molecular Teratology·Alan L ShanskeIlan E Timor-Tritsch
Mar 8, 2005·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Marilyn T MillerChristopher Gillberg
Apr 24, 2013·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·G Monni, M A Zoppi
Sep 14, 2000·Baillière's Best Practice & Research. Clinical Obstetrics & Gynaecology·E JauniauxC H Rodeck
Mar 20, 2009·Placenta·N M FiskM H F Sullivan
Mar 15, 2006·Seminars in Perinatology·Ronald J Wapner
Jan 23, 1999·Medical Decision Making : an International Journal of the Society for Medical Decision Making·P S HeckerlingN Albert
Sep 5, 2017·The Cochrane Database of Systematic Reviews·Zarko AlfirevicFaris Mujezinovic
Feb 17, 2009·The Journal of Craniofacial Surgery·Lewis B Holmes
Feb 8, 2020·Prenatal Diagnosis·Ronald J WapnerArthur L Beaudet
Mar 14, 2003·Current Opinion in Obstetrics & Gynecology·Csaba Papp, Zoltán Papp
Aug 12, 1999·Statistics in Medicine·B A BrumbackL M Ryan
Jan 1, 1997·Journal of Medical Screening·J MurrayJ Hewison
Jan 1, 1997·Prenatal Diagnosis·B L Hsi, M Adinolfi

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