Limb deformity proteins during avian neurulation and sense organ development

Developmental Dynamics : an Official Publication of the American Association of Anatomists
J L de la PompaR Zeller

Abstract

The nuclear Limb deformity (Ld) proteins (formins) are expressed during the avian primitive streak stages. Initially, they are detected predominantly in cells of the forming notochord, scattered mesodermal precursors and the induced neural plate. No expression is detected in endodermal cells. The subsequent graded distribution of Ld positive cells along the anterior-posterior axis of the neural tube follows the antero-posterior progression of its differentiation. The Ld proteins are also differentially expressed during induction and development of both the inner ear and eye. An unequal distribution of Ld proteins along the dorso-ventral axis of the otic vesicle is observed during its initial patterning. In the eye, the Ld proteins are expressed by the optic vesicle during secondary induction of the lens placode. Following induction, the proteins are also expressed by the newly formed lens placode, a process which is reminiscent of homeogenetic induction. During differentiation of the retina and lens, the Ld domains seem to demarcate territories, giving rise to specific eye structures. A comparative analysis of the Ld distribution and BrdU incorporation in the two sense organs indicates that the proteins are predominantly expres...Continue Reading

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Citations

Apr 24, 2008·BMC Evolutionary Biology·Michal GruntFatima Cvrcková
Jul 17, 2004·BMC Genomics·Fatima CvrckováViktor Zárský
Dec 6, 2000·Genome Biology·F Cvrcková
Jan 1, 2012·Scientifica·Fatima Cvrčková
Mar 15, 2016·Experimental Eye Research·Catherine ChengVelia M Fowler
Jun 20, 1998·Mechanisms of Development·M Torres, F Giráldez
Jan 1, 1996·Developmental Genetics·T F Vogt, P Leder
Dec 27, 1996·The Journal of Biological Chemistry·P UetzR Zeller

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