Limb lengthening promotes muscle growth

Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society
C S DayJ Huard

Abstract

Studies of limb lengthening have demonstrated successful bone formation in the distraction gap. Failure of the muscle units to lengthen leads to many complications that significantly limit the success of this approach; it is, therefore, of paramount importance to characterize the behavior of the muscle during limb lengthening. In this study, tibiae of adult rabbits were lengthened for 10 days at a rate of 1 mm/day. The proliferative ability of the lengthened muscle was characterized using bromodeoxyuridine, a thymidine analogue that is incorporated during cell division, and desmin, a muscle-specific marker. We observed a large number of proliferating cells, specifically in the lengthened muscle, that were co-localized with many desmin-positive cells. The presence of bromodeoxyuridine nuclei inside desmin-positive muscle fibers suggests that limb lengthening promotes muscle growth by triggering myoblast proliferation and fusion into the lengthened muscle. Our findings are consistent with those of other studies in the reviewed literature that also suggest that limb lengthening promotes muscle growth.

References

Oct 1, 1991·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·C LabrecqueJ P Tremblay
Jan 1, 1991·Pathology, Research and Practice·M D Grounds
Jan 1, 1990·Electron Microscopy Reviews·J B Harris, M J Cullen
Feb 1, 1990·Current Opinion in Cell Biology·M Stewart
Oct 1, 1989·Medicine and Science in Sports and Exercise·E Schultz
Aug 1, 1971·The Anatomical Record·F P Moss, C P Leblond
May 1, 1995·Archives of Physical Medicine and Rehabilitation·T Y ChuangT C Hsu
Dec 1, 1994·Acta Orthopaedica Scandinavica·B SchumacherI Hvid
Aug 1, 1994·Human Gene Therapy·J HuardG Karpati
Feb 1, 1994·The Journal of Clinical Investigation·J HuardJ P Tremblay
Mar 1, 1994·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·T MatanoT Kurokawa
Sep 1, 1993·Plastic and Reconstructive Surgery·K H KimJ W Futrell
Oct 1, 1961·The Journal of Biophysical and Biochemical Cytology·J ARONSON

❮ Previous
Next ❯

Citations

Feb 9, 2008·International Orthopaedics·Károly PapGyörgy Szoke
Nov 28, 2007·Archives of Orthopaedic and Trauma Surgery·A Sabri AtesalpMustafa Basbozkurt
Sep 20, 2001·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·K Hayatsu, P G De Deyne
Aug 10, 2002·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Gudrun Trøite AarnesOlav Reikerås
Dec 11, 2002·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·P G De DeyneK Jensen-Vick
Jun 9, 2012·Journal of Applied Physiology·Michael R HicksPaul R Standley
Jan 25, 2006·Investigative Ophthalmology & Visual Science·Stephen P Christiansen, Linda K McLoon
Mar 8, 2014·Clinical Orthopaedics and Related Research·Dong Hoon LeeHyun Woo Kim
Mar 29, 2006·Journal of Orthopaedic Science : Official Journal of the Japanese Orthopaedic Association·Tomoyuki TsujimuraMuneaki Abe
Mar 16, 2016·Journal of Pediatric Surgery·Nora M FullingtonHeung Bae Kim
May 29, 2012·Pathophysiology : the Official Journal of the International Society for Pathophysiology·Tüzün Fırat, Tolga Türker
May 10, 2011·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Matthew E LawlerLeonard B Kaban
Jul 28, 2007·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Masaru SatoKen Omura
Nov 18, 2006·American Journal of Orthodontics and Dentofacial Orthopedics : Official Publication of the American Association of Orthodontists, Its Constituent Societies, and the American Board of Orthodontics·Norimasa OkafujiGregory J King
Aug 30, 2008·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Ronke OlabisiKenneth J Noonan
Nov 1, 2008·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Fritz ThoreyFrank Witte
Apr 25, 2012·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Toshihiko NishishoNatsuo Yasui
Nov 1, 2016·Clinical Orthopaedics and Related Research·Hoon ParkDong Hoon Lee
Jul 12, 2002·Microsurgery·Charles S DayJohnny Huard
Sep 20, 2006·Journal of Physics. Condensed Matter : an Institute of Physics Journal·Y OhmasaM Yao
Jan 31, 2007·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Ronke OlabisiKenneth J Noonan
Mar 22, 2007·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Mohammed ElsalantyMikhail Samchukov
Aug 25, 1999·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·P G De DeyneJ E Herzenberg
May 24, 2007·Plastic and Reconstructive Surgery·Ersoy Konaş, Mehmet Emin Mavili
Oct 3, 2007·Medicine and Science in Sports and Exercise·Joke KokkonenJason B Winchester
Feb 4, 2010·Journal of Strength and Conditioning Research·Joke KokkonenJason B Winchester
Dec 21, 2012·Journal of Strength and Conditioning Research·Carmen L Borges BastosJason B Winchester
Apr 11, 2013·Journal of Orthopaedic Trauma·Michael J BeltranJoseph R Hsu
Jun 17, 2015·Journal of Applied Physiology·Dominique De JaegerWalter Herzog
Feb 26, 2005·Plastic and Reconstructive Surgery·Jack H van der MeulenWilliam M Kuzon
Oct 13, 2017·Journal of Strength and Conditioning Research·Takamasa Mizuno
Jan 31, 2020·The Journal of Craniofacial Surgery·Jürgen HolleOusmane Hamady Issa
Mar 16, 2001·Clinical Orthopaedics and Related Research·M R MakarovR D Welch
Oct 20, 2000·Clinical Orthopaedics and Related Research·P G De DeyneJ E Herzenberg
Oct 24, 2002·Clinical Orthopaedics and Related Research·Patrick G De Deyne
Sep 10, 2002·Clinical Orthopaedics and Related Research·Carrie A LindseyMikhail L Samchukov

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.