Limbal Stem Cell Deficiency: Current Treatment Options and Emerging Therapies

Stem Cells International
Michel HaagdorensNadia Zakaria

Abstract

Severe ocular surface disease can result in limbal stem cell deficiency (LSCD), a condition leading to decreased visual acuity, photophobia, and ocular pain. To restore the ocular surface in advanced stem cell deficient corneas, an autologous or allogenic limbal stem cell transplantation is performed. In recent years, the risk of secondary LSCD due to removal of large limbal grafts has been significantly reduced by the optimization of cultivated limbal epithelial transplantation (CLET). Despite the great successes of CLET, there still is room for improvement as overall success rate is 70% and visual acuity often remains suboptimal after successful transplantation. Simple limbal epithelial transplantation reports higher success rates but has not been performed in as many patients yet. This review focuses on limbal epithelial stem cells and the pathophysiology of LSCD. State-of-the-art therapeutic management of LSCD is described, and new and evolving techniques in ocular surface regeneration are being discussed, in particular, advantages and disadvantages of alternative cell scaffolds and cell sources for cell based ocular surface reconstruction.

References

Mar 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·E BellC Merrill
Sep 1, 1995·American Journal of Ophthalmology·K NishidaS Yamamoto
Apr 9, 1994·BMJ : British Medical Journal·H I Atrah
Oct 1, 1995·Ophthalmology·V Puangsricharern, S C Tseng
Nov 6, 1998·Science·J A ThomsonJ M Jones
Feb 4, 1999·The British Journal of Ophthalmology·H S Dua
Mar 29, 2000·Survey of Ophthalmology·H S Dua, A Azuara-Blanco
Jul 13, 2000·The New England Journal of Medicine·R J TsaiJ K Chen
Aug 30, 2000·Biochemical Society Transactions·J MyllyharjuK I Kivirikko
Apr 24, 2001·The British Journal of Ophthalmology·D F AndersonS C Tseng
Jul 11, 2001·Experimental Biology and Medicine·L LuW W Kao
Jul 21, 2001·American Journal of Otolaryngology·K H SiedentopK M O'Grady
Sep 15, 2001·Journal of Biomaterials Science. Polymer Edition·K MerrettH Sheardown
Mar 19, 2002·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·J T DanielsP T Khaw
Aug 6, 2002·Journal of Biomaterials Science. Polymer Edition·L AucoinH Sheardown
Dec 17, 2002·Nature Biotechnology·Masahiro TomitaKatsutoshi Yoshizato
Dec 31, 2002·Investigative Ophthalmology & Visual Science·Takahiro NakamuraShigeru Kinoshita
Jan 25, 2003·The British Journal of Ophthalmology·I JalbertM Coroneo
Apr 18, 2003·Biomaterials·Eugene Khor, Lee Yong Lim
Nov 19, 2003·Advanced Drug Delivery Reviews·David OlsenJames Polarek
Jan 20, 2004·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·J BergerR Gurny
Feb 24, 2004·The British Journal of Ophthalmology·A JosephH S Dua
Mar 19, 2004·Journal of Biomaterials Science. Polymer Edition·Haifeng LiuYilin Cao
May 6, 2004·American Journal of Ophthalmology·Blonie W Dudney, Monika A Malecha
Sep 17, 2004·The New England Journal of Medicine·Kohji NishidaYasuo Tano

❮ Previous
Next ❯

Citations

Sep 21, 2016·Stem Cells International·Thomas A HogerheydeNeil A Richardson
Dec 13, 2016·Ocular Immunology and Inflammation·Ashik MohamedVirender S Sangwan
Dec 23, 2016·Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft·K SpaniolS Schrader
Jun 13, 2017·International Journal of Molecular Sciences·Anne BukowieckiSabine A Eming
Feb 24, 2018·Expert Opinion on Biological Therapy·Yuzuru SasamotoNatasha Y Frank
Oct 1, 2019·Journal of Cataract and Refractive Surgery·Michael Murri
Dec 31, 2017·EMBO Molecular Medicine·Robert E HyndsSam M Janes
Feb 23, 2020·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Juan Carlos Serna-OjedaYonathan Garfias
Mar 25, 2020·Investigative Ophthalmology & Visual Science·Alessandra MiceraStefano Bonini
Feb 9, 2018·Medicine·Dorota RaczyńskaKrystyna Raczyńska
Mar 10, 2018·Anaesthesia and Intensive Care·Awy ChuaPca Kam
Apr 13, 2018·International Journal of Molecular Sciences·Noriaki NagaiYoshikazu Shimomura
May 9, 2019·Stem Cells International·Michel HaagdorensMarie-José Tassignon
Nov 28, 2017·Seminars in Ophthalmology·Jia Yin, Ula Jurkunas
Aug 16, 2019·Cells·Yu HanJianxun Ding
Jun 28, 2019·Frontiers in Bioengineering and Biotechnology·Mohammadmahdi MobarakiMasoud Mozafari
Jan 4, 2017·Stem Cells International·Nuria Nieto-NicolauRicardo P Casaroli-Marano
Nov 9, 2018·Stem Cells International·Marta SacchettiAlessandro Lambiase
Dec 4, 2019·Scientific Reports·Aya InamochiSatoru Yamagami
Apr 13, 2017·Neural Regeneration Research·Israel AharonyNitza Goldenberg-Cohen
May 6, 2020·Scientific Reports·Lavanya KalaimaniGowri Priya Chidambaranathan
Jun 20, 2019·International Journal of Molecular Sciences·Hassan MansoorGary Hin-Fai Yam
Sep 24, 2019·Molecular Medicine Reports·Shankargouda PatilPraveenkumar Shetty
Jul 11, 2018·International Journal of Molecular Sciences·Zhi Hou GuoJun Sheng Lin
Feb 13, 2021·Genesis : the Journal of Genetics and Development·Mohd Tayyab Adil, Jonathan J Henry
Feb 3, 2021·International Journal of Molecular Sciences·Louis-Philippe GuérinSylvain L Guérin
May 6, 2021·Journal of Cellular and Molecular Medicine·Núria Nieto-NicolauRicardo P Casaroli-Marano

❮ Previous
Next ❯

Methods Mentioned

BETA
confocal microscopy
dissection
biopsies
biopsy
scraping
dissecting

Software Mentioned

COMET
Holoclar
IVCM

Related Concepts

Related Feeds

Adult Stem Cells

Adult stem cells reside in unique niches that provide vital cues for their survival, self-renewal, and differentiation. They hold great promise for use in tissue repair and regeneration as a novel therapeutic strategies. Here is the latest research.

Anti-inflammatory Treatments

A drug or substance that reduces inflammation (redness, swelling, and pain) in the body. Anti-inflammatory agents block certain substances in the body that cause inflammation and swelling. Discover the latest research on anti-inflammatory treatments here

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.

Angiogenesis Inhibitors to Treat Cancer

Cancer treatments including angiogenesis inhibitors prevent tumor cells from receiving nutrients and oxygen. Here is the latest research on angiogenesis inhibitors for the treatment of cancer.